First description of rpsJ and mepA mutations associated with tigecycline resistance in Staphylococcus aureus isolated from a cystic fibrosis patient during antibiotic therapy

Vancomycin remains the gold standard of treatment for methicillin-resistant Staphylococcus aureus (MRSA) serious infections; however, the emergence of strains with reduced vancomycin susceptibility warrants the need for alternative therapies. Tigecycline (TGC) is a broad-spectrum protein synthesis inhibiting antibiotic that is active against Gram-positive and Gram-negative organisms, including multidrug-resistant (MDR) bacteria. The FDA approved its use for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research

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Publication date: Available online 22 August 2019Source: Advances in Virus ResearchAuthor(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbre...
Source: Advances in Virus Research - Category: Virology Source Type: research
In this study, we successfully developed new thiol chitosan-wrapped gold nanoshells (TC-AuNSs) as an antibacterial agent for the near-infrared (NIR) laser-triggered photothermal destruction of antibiotic-resistant pathogens, such as Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), owing to their high water solubility, biocompatibility, strong NIR absorption, and outstanding photothermal properties. More interestingly, TC-AuNSs (115 µg/mL) were capable of completely destroying S. aureus, P. aeruginosa, and E.coli within 5 min of NIR ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
In this study, LNPs were prepared from corncob lignin via anti-solvent precipitation method, and then characterized by FTIR, TGA, AFM, and NMR. The CNF@CLNPs composite film was fabricated by blending CLNPs with CNF. The results showed that the CLNPs had an average diameter of about 118 nm, meanwhile the main structures and properties of corncob lignin were maintained. The CNF@CLNPs composite film exhibited a high ultraviolet resistance, and a good antibacterial activity against both Escherichia coli and Staphylococcus aureus. It is expected that the CNF@CLNPs composite film would have potential applications in outdo...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
CONCLUSIONS: There was a great diversity of oral, craniofacial and systemic characteristic among the KS patients, suggesting that an inter-disciplinary approach should be taken for their dental treatment. PMID: 31433389 [PubMed - as supplied by publisher]
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
Publication date: 15 January 2020Source: Journal of Hazardous Materials, Volume 382Author(s): Jian Lu, Yuxuan Zhang, Jun Wu, Jianhua Wang, Ying CaiAbstractThe fate of antibiotic resistance genes (ARGs) in reclaimed water reuse system with integrated membrane process (IMR) was firstly investigated. Results indicated that ARGs, class 1 integrons (intI1) and 16S rRNA gene could be reduced efficiently in the IMR system. The absolute abundance of all detected ARGs in the reuse water after reverse osmosis (RO) filtration of the IMR system was 4.03 × 104 copies/mL, which was about 2–3 orders of magnitude lower tha...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Authors: Hosoda T, Sakamoto M, Orikasa H, Kubomura A, Misaki T, Okabe N Abstract Recently, severe cases of infection due to hypermucoviscous Klebsiella pneumonia (hmKP) have been reported in Japan. The Amami Islands in Japan are also endemic regions for Strongyloides stercoralis. Disseminated strongyloidiasis strain often causes severe enterobacteria infection; however, whether or not chronic strongyloidiasis induces it remains unclear. We herein report a 71-year-old man who developed meningitis and liver abscess due to hmKP complicated with chronic strongyloidiasis. He died on the seventh hospital day. Strongyloid...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Nakamura H, Nakayama D, Tanaka S, Horita T PMID: 31434824 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
This study retrospectively evaluated the safety, impact on growth, and clinical outcomes of gastrojejunostomy tubes (GJTs) converted from surgically placed gastrostomy tubes (GTs) in 44 developmentally disabled children (median age: 28 months). The total duration of GJT follow-up was 31,378 device-days (median: 643 device-days). Three major complications (aspiration pneumonia) were identified in 3 patients (6.8%), 63 minor complications in 31 patients (70.5%), and 202 tube maintenance issues (TMIs) in 41 patients (93.2%). A significantly increased average change in weight-for-age z-scores was observed at each 6-month inter...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research
Conclusions: Liver US patterns in children with CF correlate with platelet count, spleen size and indices of liver fibrosis. Multivariable models of these biomarkers have excellent discriminating ability for NL versus NOD, and good ability to distinguish other US patterns, suggesting that US patterns correlate with clinically relevant liver disease.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Guidelines recommend breastfeeding in cystic fibrosis (CF) but breastfeeding rates decline rapidly in CF. We initiated a quality improvement project to improve breastfeeding in CF by incorporating International Board-Certified Lactation Consultants (IBCLC) into the initial CF-diagnosis visit to support mothers who were breastfeeding at diagnosis. In the preintervention group, only 8/14 (57%) continued to provide breast milk after the first visit, whereas postintervention, 16/17 (94%) mothers continued to do so (P = 0.03). The duration of any (or partial) breastfeeding increased to an average of 7.7 months from an avera...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communication: Pancreatology Source Type: research
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