First description of rpsJ and mepA mutations associated with tigecycline resistance in Staphylococcus aureus isolated from a cystic fibrosis patient during antibiotic therapy

Vancomycin remains the gold standard of treatment for methicillin-resistant Staphylococcus aureus (MRSA) serious infections; however, the emergence of strains with reduced vancomycin susceptibility warrants the need for alternative therapies. Tigecycline (TGC) is a broad-spectrum protein synthesis inhibiting antibiotic that is active against Gram-positive and Gram-negative organisms, including multidrug-resistant (MDR) bacteria. The FDA approved its use for the treatment of complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research

Related Links:

OBJECTIVES: To first describe the epidemiological data of burns, including burn types and burn-related infections, in adult and pediatric patients. Second, to determine the effect of Methicillin-Resistant Staphylococcus aureus (MRSA) on length of hospital ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
This study aimed to investigate the nutritional status of and feeding practices for dysphagic older adult inpatients in some Vietnamese hospitals. The study was designed as a cross-sectional study and was conducted in three large hospitals in northern Vietnam. The data for 1007 older inpatients (58.3% were females, mean age was 75.5±7.3 y) about their dysphagic status, nutritional status and feeding practices were collected by dietitians. About 29% of the older adult inpatients suffered from malnutrition and 54% had a risk of malnutrition. Half of the dysphagia group had malnutrition and 42% were at risk of malnutri...
Source: Journal of Nutritional Science and Vitaminology - Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research
Publication date: Available online 2 July 2020Source: IDCasesAuthor(s): Vaia Derveni, Evangelos Kaniaris, Dimitris Toumpanakis, Efstathia Potamianou, Ilianna Ioannidou, Danai Theodoulou, Anna Kyriakoudi, Magda Kyriakopoulou, Konstantinos Pontikis, Maria Daganou
Source: IDCases - Category: Infectious Diseases Source Type: research
Conclusion: Few case reports detail the appropriate anesthetic considerations for cases of VPS migration. This report describes shunt migration pathophysiology and patient assessment with a focus on anesthetic preparation and management for this rare complication. PMID: 32612485 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
AbstractThere is an increasing evidence that strict evaluation of clinical signs is effective in detecting newborns at risk of early-onset sepsis (EOS) that require antibiotic therapy. In a retrospective case control design, we compared EOS antibiotic indication by clinical signs surveillance with multivariate risk analysis (EOSCalc), and estimate their costs. Newborns ≥ 34 weeks who received EOS antibiotics from June 2014 to December 2016 were studied. Were considered symptomatic those with three clinical signs within first 24 h or two signs and one risk factor present. Cost estimative was done using b...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
In this study, a series of new 4-hydroxy-2-quinolinone analogs containing a long alkyl side chain at C-3 and a broad range of substituents on the C-6 and C-7 positions were synthesized. The antibacterial and antifungal activities of these analogs against Staphylococcus aureus, Escherichia coli, and Aspergillus flavus were investigated. The structure-activity relationship study revealed that the length of the alkyl chain, as well as the type of substituent, has a dramatic impact on the antimicrobial activities. Particularly, the brominated analogs 3j with a nonyl side chain exhibited exceptional antifungal activities agains...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusions: Results showed a high level of oxacillinases producing A. baumannii circulating in our study setting, highlighting the need for local molecular surveillance to inform appropriate management and prevention strategies. PMID: 32612659 [PubMed]
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Publication date: 1 December 2020Source: Chemical Engineering Journal, Volume 401Author(s): Xiao-Fei Liu, Jun Zhang, Jiang-Jun Liu, Qi-Hui Zhou, Zhongqiang Liu, Peng-Yue Hu, Zhe Yuan, Seeram Ramakrishna, Da-Peng Yang, Yun-Ze Long
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
CONCLUSION: infectious complications were the most prevalent postoperatively. The scarcity of guidelines that guide the monitoring of complications regarding monitoring frequency, follow-up time and classification makes it difficult to establish an overview of them and consequently propose intervention strategies. PMID: 32609217 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
Abstract In medical care, qualified physicians, nurses, and pharmacists have come to be recognized as a team integral to a patient's success, and this team approach to medical care has become popular. In the infectious disease field, more hospitals are practicing antimicrobial stewardship as a team, in addition to the conventional infection control team (ICT). As a result, infectious disease chemotherapy pharmacists are in demand. However, this specific qualification is hard to acquire for pharmacists working in a primary care pharmacy. The problem of multidrug-resistant bacteria is of vital interest today. The Na...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
More News: Alternative and Complementary Therapies | Antibiotic Therapy | Bacterial Pneumonia | Complementary Medicine | Cystic Fibrosis | Drugs & Pharmacology | Infectious Diseases | MRSA | Multidrug Resistance | Pneumonia | Skin | Staphylococcus Aureus | Superbugs