Medtronic, Mercy hospitals ink data-sharing deal

Medtronic (NYSE:MDT) and the Mercy healthcare system today said they inked a data sharing and analysis deal to gather clinical evidence for “medical device innovation and patient access.” The program aims to gather efficacy and safety data generated during routine care, rather than via expensive and time-consuming clinical trials. The first phase is designed to collect anonymized data from some 80,000 heart failure patients treated with cardiac resynchronization therapy. “Having the ability to study patient care pathways and conditions before and after exposure to a medical device is crucial to understanding how those devices perform outside of the controlled clinical trial setting,” strategic scientific operations SVP Dr. Rick Kuntz said in prepared remarks. “By partnering together, Mercy and Medtronic have set out to create a comprehensive and economical evidence generation model that ultimately allows patients to benefit from the latest therapies and technologies as early as possible.” “This has the potential to improve patient care by using advanced data analytics,” added Dr. Joseph Drozda, director of outcomes research at Mercy, the nation’s fifth-largest Catholic healthcare network. “Heart failure is a complex, progressive condition. To more effectively treat patients, we need a better understanding of how they are responding to treatment and what leads to better health. This model will lead to evidence-based i...
Source: Mass Device - Category: Medical Devices Authors: Tags: Big Data Hospital Care Wall Street Beat Medtronic Source Type: news

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In conclusion, our case showed a strong beneficial effect of Sacubitril/Valsartan on reverse remodeling and LVEF beyond the benefits of concomitant optimal medical therapy. This result is particular noteworthy because it was obtained although patient wasn't able to reach the full dose of the drug. Physician should always consider this drug effect when more demanding therapeutic strategies are needed for their HF patients. PMID: 30894032 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Most cardiac implants, such as pacemakers and AICDs, are designed to correct the underlying heart’s rhythm, and synchronize atrial and ventricular contractions. That’s how these devices can improve cardiac performance in people with heart...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Source Type: blogs
The objective of this study was to evaluate the relationship between electrocardiogram (ECG) parameters and LVPET in patients with CRT.MethodsIt was an observational, prospective, and monocentric study. From May 2017 to October 2017, all patients who underwent CRT with left quadripolar lead in Rouen University Hospital were included. LVPET was evaluated by echocardiography and defined as the time between the beginning of the QRS and the beginning of pulsed Doppler signal positioned in left ventricular outflow tract in apical view. The following parameters on 12-leads ECG were assessed: QRS width in V3, sum of QRS amplitude...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Cardiac resynchronization therapy (CRT) improves quality of life and survival in patients with heart failure, but it has not been rigorously investigated in LVAD patients. Furthermore, the effects of different pacing strategies on hemodynamics in LVAD recipients is unknown.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 91 Source Type: research
We present the full study cohort of the first prospective study evaluating outcomes with right ventricular (RV) vs biventricular (BiV) pacing in LVAD patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 90 Source Type: research
Exercise-induced left bundle branch block (LBBB) is rarely observed in exercise testing, and usually implies a worse prognosis. Cardiac resynchronization therapy (CRT) is well validated in patients with heart failure with reduced ejection fraction (HFrEF) and LBBB. Although the indications of CRT do not include exercise-induced LBBB, the functional impairment secondary to dynamic electromechanical dyssynchrony could potentially be improved with CRT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 71 Source Type: research
Cardiac resynchronization therapy (CRT) has been shown to shorten QRS duration (QRSd) and improve ejection fraction (EF) in adults with congenital heart disease (ACHD) and children with heart failure with reduced ejection fraction (HFrEF). It is not known whether CRT confers a survival benefit. We sought to determine whether CRT is associated with longer transplant-free survival after adjusting for patient factors.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 478 Source Type: research
ABSTRACTBackground and aimsPatients with moderate ‐to‐severe chronic kidney disease (CKD) are underepresented in clinical trials of cardiac resynchronization therapy (CRT)‐defibrillation or CRT‐pacing (CRT‐P). We sought to determine whether outcomes after CRT‐D are better than after CRT‐P over a wide spectrum of CKD.Methods and resultsClinical events were quantified in relation to pre ‐implant estimated glomerular filtration rate (eGFR) after CRT‐D (n = 410 [39.2%]) or CRT‐P (n = 636 [60.8%]) implantation. Over a follow‐up period of 3.7 years (median, interquartile range: 2.1‐5.7), the eGFR
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: DEVICES Source Type: research
Cardiac resynchronization therapy (CRT) improves mortality, morbidity and quality of life in selected heart failure patients with severe left ventricular ejection fraction impairment. However, between 20% and 40% of device recipients do not benefit clinically from CRT. Indeed, some anatomical and technical difficulties are related to the coronary venous implantation site via the coronary sinus (CS). Additionally, electrical constraints have been described and CS does not always correspond to the optimal LV lead position.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
ConclusionDaily multiparameter telemonitoring has a potential to reduce clinical endpoints in patients with chronic systolic heart failure both in ICD and CRT-D subgroups. The absolute benefit seems to be higher in higher-risk populations with worse prognosis.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
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