Increased amputation risk with canagliflozin treatment: behind the large cardiovascular benefit?

A growing body of evidence suggests that sodium-glucose cotransporter 2 (SGLT2) inhibitors appear to be a powerful option to improve the cardiovascular (CV) prognosis in high CV-risk patients with type 2 diabe...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Commentary Source Type: research

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This study was registered with ClinicalTrials.gov, number NCT02424500.FindingsBetween Feb 2, 2015, and March 17, 2017, 236 patients were screened for eligibility, of whom 181 (77%) were enrolled and randomly assigned to the intervention (n=93) and control (n=88) groups. At baseline, mean HbA1c was 8·7% (SD 0·8; 72 mmol/mol [SD 8·8]) in the intervention group and 8·5% (SD 0·8; 69 mmol/mol [SD 8·8]) in the control group. The mean decrease in HbA1c from baseline to 6 months was 1·0% (SD 1·0; 11 mmol/mol [SD 11]) in the intervention group, and 0·3% (SD 0·9; ...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 22 February 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Jaakko Tuomilehto
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Maria Inês Schmidt, Paula A Bracco, John S Yudkin, Isabela M Bensenor, Rosane Härter Griep, Sandhi Maria Barreto, Cristina D Castilhos, Bruce B DuncanSummaryBackgroundThe burden of diabetes is increasing worldwide and diabetes can be prevented with intervention in people with impaired glucose tolerance (IGT). Intermediate hyperglycaemia defined without an oral glucose tolerance test as impaired fasting glucose (IFG) and high HbA1c are also used to characterise risk. We aimed to assess the prognostic proper...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): María M. Adeva-Andany, Julia Martínez-Rodríguez, Manuel González-Lucán, Carlos Fernández-Fernández, Elvira Castro-QuintelaAbstractDiabetes is a common metabolic disorder associated to elevated cardiovascular morbidity and mortality that is not explained by hyperglycemia or traditional cardiovascular risk factors such as smoking or hypercholesterolemia. Intensive glycemic control with insulin that achieves near-normal glycemia does not reduce s...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Abstract Type 2 diabetes is a prevalent chronic health condition more frequently affecting adults ages 65 and older. Furthermore, these individuals tend to have more type 2 diabetes-associated complications, compared with younger individuals with diabetes, and face unique challenges throughout the self-management process. Despite many studies and reviews about diabetes self-management, few researchers focus specifically on older adults. Of particular importance is the need to understand self-management challenges through the patient's lens. Therefore, the purpose of the current review is to examine and summarize t...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
Publication date: Available online 22 February 2019Source: Clinica Chimica ActaAuthor(s): Beatrice Campi, Simone Codini, Niccolò Bisoli, Simona Baldi, Riccardo Zucchi, Ele Ferrannini, Alessandro SabaAbstractThe present paper describes the development and the validation process – in compliance with the EMA guidelines – of a method based on tandem mass spectrometry coupled to liquid chromatography for the accurate quantification of mannose in human plasma samples. The quick sample preparation procedure, simplified by the absence of any derivatization step, makes the assay suitable for routine use in a clin...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
TYPE 2 diabetes sufferers are advised to eat healthily in order to control the condition, but everyone deserves a treat every now and then. Burgers are generally considered an unhealthy food, but if you have diabetes and love a burger, this is the type you should opt for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
TYPE 2 diabetes sufferers are advised to eat healthily in order to control the condition, but everyone deserves a treat every now and then. Burgers are generally considered an unhealthy food, but if you have diabetes and love a burger, this is the type you should opt for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
When Tom Shicowich’s toe started feeling numb in 2010, he brushed it off as a temporary ache. At the time, he didn’t have health insurance, so he put off going to the doctor. The toe became infected, and he got so sick that he stayed in bed for two days with what he assumed was the flu. When he finally saw a doctor, the physician immediately sent Shicowich to the emergency room. Several days later, surgeons amputated his toe, and he ended up spending a month in the hospital to recover. Shicowich lost his toe because of complications of Type 2 diabetes as he struggled to keep his blood sugar under control. He wa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health Nutrition Source Type: news
AbstractMexican-Americans carry a high burden of type 2 diabetes and are disproportionately affected by diabetes related mortality and morbidity. Poor adherence to medication is an important barrier to achieving metabolic control and contributes to adverse health outcomes and health disparities. Little is known about barriers and facilitators to medication adherence among Mexican-Americans with diabetes. This is a qualitative study of semi-structured interviews with a sample of 27 adults (25 Mexican-Americans and 2 Latinos of other origin) with self-reported type 2 diabetes who were recruited as part of a church-based, ran...
Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
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