Increased amputation risk with canagliflozin treatment: behind the large cardiovascular benefit?

A growing body of evidence suggests that sodium-glucose cotransporter 2 (SGLT2) inhibitors appear to be a powerful option to improve the cardiovascular (CV) prognosis in high CV-risk patients with type 2 diabe...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Commentary Source Type: research

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Once-weekly dulaglutide is effective for glycemic control in patients with type 2 diabetes and moderate to severe kidney disease, while helping to slow renal function decline, new research shows.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Shih-Yi Lin, Wu-Huei Hsu, Cheng-Chieh Lin, Cheng-Li Lin, Chun-Hao Tsai, Hung-Chieh Yeh, Chung-Y. Hsu, Chia-Hung Kao
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Allegheny Health Network has opened a new office at its hospital in Bloomfield to treat obesity, diabetes and other endocrine disorders. The Bariatric and Metabolic Institute at West Penn Hospital is now open on the second floor of the hospital's Mellon Pavilion, according to a news release. Obesity is a leading risk factor for Type 2 diabetes, so to meet the needs of patients, the AHN Center for Diabetes and Endocrine Health is a part of the institute along with the AHN Comprehensive Weight Management…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
___ Getting kids outside and active could help with brain health: Participaction report (The Globe and Mail): “The physical benefits of kids leading an active lifestyle, including better heart health and a decreased risk of developing Type 2 diabetes, are well known. But a growing body of research suggests there are significant mental benefits as well, whether it’s lowering stress levels or helping to treat anxiety and depression. A new report released by Participaction on Tuesday draws attention to this link, and by doing so, hopes to encourage kids in Canada to get moving more. The Report Card on Physical Act...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness anxiety brain-function Brain-health Canada depression diabetes heart heart health improve-cognition lifestyle mental benefits Mental-Health stress-levels Source Type: blogs
DIABETES type 2 could be treated by making diet or exercise changes. You can lower your risk of high blood sugar symptoms by making sure you eat these types of cheese, it ’s been claimed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionGlycemic improvement by probiotics and particularly synbiotic supplements in prediabetic individuals has been supported by current study. However, further studies are required for optimal recommendations in this important area of patient treatment.Trial registrationIranian Registry of Clinical Trials: IRCT201511032321N2, Date registered February 27, 2016.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
This study designed to observe the effect of KWZ on glucose consumption and assess the molecular mechanism on associated proteins in insulin signaling and ER stress pathway in L6 rat skeletal muscle cells. The results showed that, KWZ exhibited proteins of PTP-1B and α-glycosidase inhibitory activity in vitro. No cytotoxicity of KWZ was found on L6 cell line. The best effect of glucose consumption of cells was shown at 6.25 μg/mL after KWZ treatment for 12 hours. Expression of PTP-1B protein was inhibited by KWZ in L6 moytubes. PI3K-dependent Akt phosphorylation was found to be activated by KWZ. Moreover, the insu...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Diabetic Medicine, EarlyView.
Source: Diabetic Medicine - Category: Endocrinology Authors: Source Type: research
Publication date: Available online 21 June 2018 Source:The Journal of Foot and Ankle Surgery Author(s): Amandine Bonte, Nicolas Bertheuil, Tiphaine Menez, Jean-louis Grolleau, Christian Herlin, Benoit Chaput The proximally based medial plantar flap is considered to be the reference standard for heel reconstruction. Although less well-studied, a distally based medial plantar flap is a suitable alternative when used to cover a distal foot defect, especially of the hallux, first metatarsal, or metatarsophalangeal joint. Our objective was to provide a complete description and propose a classification of the different surgical...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 21 June 2018 Source:The Journal of Foot and Ankle Surgery Author(s): Jonathan M. Labovitz, Jarrod M. Shapiro, V. Kathleen Satterfield, Nathanael T. Smith The purpose of the present study was to demonstrate the effect of a delayed diagnosis of Charcot foot on acute care cost and usage. We used International Classification of Disease, Ninth Revision, Clinical Modification codes, and the California Office for Statewide Health Planning and Development 2009 to 2012 public patient discharge files to identify patients with type 2 diabetes mellitus and Charcot foot. The costs and length of stay ...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
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