Sensors, Vol. 17, Pages 2341: Verification of a Method for Measuring Parkinson ’s Disease Related Temporal Irregularity in Spiral Drawings

Sensors, Vol. 17, Pages 2341: Verification of a Method for Measuring Parkinson’s Disease Related Temporal Irregularity in Spiral Drawings Sensors doi: 10.3390/s17102341 Authors: Somayeh Aghanavesi Mevludin Memedi Mark Dougherty Dag Nyholm Jerker Westin Parkinson’s disease (PD) is a progressive movement disorder caused by the death of dopamine-producing cells in the midbrain. There is a need for frequent symptom assessment, since the treatment needs to be individualized as the disease progresses. The aim of this paper was to verify and further investigate the clinimetric properties of an entropy-based method for measuring PD-related upper limb temporal irregularities during spiral drawing tasks. More specifically, properties of a temporal irregularity score (TIS) for patients at different stages of PD, and medication time points were investigated. Nineteen PD patients and 22 healthy controls performed repeated spiral drawing tasks on a smartphone. Patients performed the tests before a single levodopa dose and at specific time intervals after the dose was given. Three movement disorder specialists rated videos of the patients based on the unified PD rating scale (UPDRS) and the Dyskinesia scale. Differences in mean TIS between the groups of patients and healthy subjects were assessed. Test-retest reliability of the TIS was measured. The ability of TIS to detect changes from baseline (before medication) to later time points was investigated. Correlations betw...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research