Factor VII-activating protease: sex-related association with coronary artery calcification

Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing the study population in three groups: (1) Agatston score = 0 U, (2) Agatston score = 1–99 U, or (3) Agatston score more than 99 U. A total of 134 women and 116 men were included. Total FSAP, FSAP GP, and specific FSAP activity were independently higher in women (97.4%, 81.1%, 0.84, respectively) compared with men (87.5%, 68.7%, 0.79, respectively) (P 
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: Original Articles Source Type: research

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Conclusion-The results could help the researchers to investigate the possible role of the environmental electromagnetic fields on the promotion of diabetes disease. PMID: 29792541 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Authors: Lipiecki J, Brunel P, Morice MC, Roguelov C, Walsh SJ, Richardt G, Eerdmans P, Zambahari R, Berland J, Copt S, Stoll HP, Urban P Abstract AIMS: The LEADERS FREE trial has demonstrated that a polymer-free Biolimus A9-coated stent (BA9-DCS) is superior to a bare metal stent (BMS) for high bleeding risk (HBR) patients when treated with one month of dual antiplatelet therapy (DAPT). This analysis aimed to determine the impact of PCI procedure complexity on the two-year results. METHODS AND RESULTS: Six hundred and sixty-seven (667) patients enrolled in the LEADERS FREE (BA9-DCS 346, BMS 321) underwent a co...
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
CONCLUSIONS: This is the first study providing clinical evidence on the use of PF-BES in all-comer patients irrespective of HBR status. Our findings suggest that PF-BES has a favorable safety and efficacy profile in a real world clinical setting. Further investigation in randomised clinical trials against new-generation DES is warranted. PMID: 29784631 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
DIABETES type 2 symptoms include unexplained weight loss, tiredness and frequently needing the toilet. If you develop the condition it is important to take steps to control your blood sugar levels, as failing to do so can cause further life threatening problems. These are seven problems you can develop due to the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Our weekly DiabetesMine advice column explores reasons why people with diabetes sometimes get low blood sugar even when they dose insulin just right.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
DIABETES type 2 is more likely to appear as we get older, while diabetes type 1 usually appears shortly after birth. Diabetes symptoms include frequently needing the loo, feeling more hungry and thirsty than usual and unexplained weight loss. If you suffer from the condition, you should eat this much fruit and veg a day in your diet to help maintain your blood sugar levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 47-year-old man is evaluated during a follow-up examination. He is obese and has hypertension, type 2 diabetes mellitus, and obstructive sleep apnea. He reports that he has always has been overweight, and over the years, his weight has gradually increased to 123 kg (271 lb). During the past 2 years, he has tried several commercial diets; a dietician-monitored, calorie-restricted diet; increased physical activity; orlistat; and a combination of these interventions, all without achieving sustained weight...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Primary Care Source Type: blogs
A surprising (but welcome) side effect of a therapy for obsessive-compulsive disorder may pave the way for a new approach to treating type 2 diabetes — and offer new insights into the links between obesity and the metabolic disease that afflicts close to 1 in 10 American adults.The therapy in...
Source: Los Angeles Times - Science - Category: Science Authors: Source Type: news
DIABETES type 2 is more likely to appear as we get older, while diabetes type 1 usually appears shortly after birth. Diabetes symptoms include frequently needing the loo, feeling more hungry and thirsty than usual and unexplained weight loss. If you suffer from the condition, you should eat this much fruit and veg a day in your diet to help maintain your blood sugar levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
DIABETES type 2 is more likely to appear as we get older, while diabetes type 1 usually appears shortly after birth. Diabetes symptoms include frequently needing the loo, feeling more hungry and thirsty than usual and unexplained weight loss. If you suffer from the condition, you should eat this much fruit and veg a day in your diet to help maintain your blood sugar levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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