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AcelRx Pharma shares sink as FDA rejects opioid painkiller

(Reuters) - Shares of AcelRx Pharmaceuticals Inc plunged more than 60 percent on Thursday after the U.S. Food and Drug Administration declined to approve its opioid painkiller Dsuvia.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Conclusion and ImplicationsThese data suggest that resolvins or their mimetics may prove useful novel therapeutics in diseases such as pulmonary arterial hypertension, which are characterised by increased thromboxane contractile activity.
Source: British Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: RESEARCH PAPER Source Type: research
Abstract AimTo evaluate lymphocyte‐like cell activation (CD5‐positive cells) and the expression of interleukin (IL)‐6 and IL‐17 in the pulp after dental bleaching with two concentrations of hydrogen peroxide (H2O2). MethodologyThe right and left maxillary molars from 40 rats were treated randomly with bleaching gel with 20% H2O2 (BLUE group, 1 application of 50 min), 35% H2O2 (MAXX group, 3 applications of 15 min), or placebo gel (Control). After 2 and 30 days, the rats were killed (n=10), and the jaws were processed for histological and immunohistochemistry analysis of the pulp tissue. The scores of inflammation a...
Source: International Endodontic Journal - Category: Dentistry Authors: Tags: Original Scientific Article Source Type: research
THE benefits of statins are exaggerated and their side effects downplayed, claims a new report calling for all trial data on the drug to be released “as a matter of urgency”.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Arizona officials' plan to deal with the rising crisis of opioid addiction is to limit the amount of pills doctors could prescribe. Legislation coming from Gov. Doug Ducey would seek to bar physicians from prescribing more than five days of the pain killers at a time and cap the amount of pills given to people who suffer from chronic pain, according to Ktar.com. The limits as well as increased regulation of pain clinics would be part of the plan. The legislation, however, has not been finished. Opiods…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
This study shows the first detection of Chlamydiaceae and C. abortus DNA on reproductive losses of bovine cattle in Argentina, and the described prevalence value (4.78%) should be taken as baseline value due to the type of samples analyzed. Detection of genetic material from Chlamydiaceae not matching any of the studied species could be due to intraspecies variants or local species not yet described. Further research on Chlamydia infections in bovine cattle in Argentina is imperative to describe their range, to analyze their economic and zoonotic implications and to make recommendations about prevention and control measure...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
Authors: Dai J, Liu J, Zhou M, Wang W, Xu ZD, Wang N Abstract BACKGROUND Congenital single-side deafness (SSD) affects sound localization even after cochlear implantation (CI) in some conditions. The medial nucleus of the trapezoid body (MNTB) plays an important role in binaural benefit and sound localization, but little is known about intrinsic molecular changes in MNTB with SSD. We aimed to observe changes in MNTB in early-developmental SSD rats, including the key neurotransmitters (GABA, Gly, Glu) and major receptors (GABAa-R/GABAb-R for GABA, Gly-R for Gly, and AMPA/NMDA for Glu). MATERIAL AND METHODS The model...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The findings indicate that the BTLA/HVEM pathway does be involved in pathogenesis of acute rejection following kidney transplantation, as well as the induction of transplant tolerance. This pathway may therefore be a useful target for therapy against acute rejection after kidney transplantation. PMID: 29352109 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
For some of you, the New Year has already started, but I’ve been in a lovely position where I’ve been on leave and haven’t yet started “work” – though the work of living is always present! It’s traditional at this time to year to review the past year and plan for the coming months, so today’s post is a few musings on both. Last year I noticed I’d been working on this blog for nearly 10 years! Astonishing really, because it was intended to be a learning experience for me during my recovery from a mTBI. It kinda grew like Topsy, and here I am 10 years down the road still ...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Uncategorized healthcare biopsychosocial Pain pain management allied health Source Type: blogs
Health Literacy: Exploring Nursing Challenges to Providing Support and Understanding
. Clin J Oncol Nurs. 2018 Feb 01;22(1):53-61 Authors: Wittenberg E, Ferrell B, Kanter E, Buller H Abstract BACKGROUND: As patient advocates, oncology nurses must attend to varying levels of health literacy among patients and families. However, little is known about nurses' experiences and comfort with health literacy assessment and providing health literacy support.
. OBJECTIVES: The purpose of this study is to explore nurse communication and patient health literacy.
. METHODS: A cross-sectional survey...
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
This article presents a case study for nursing consideration. PMID: 29350713 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
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