Stroke Risk Factors Are Rising

More people survive these brain attacks, but the health problems that cause stroke aren't going away
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Conclusions: The current findings indicate that MST1 participates in SAH-induced BBB disruption and white matter fiber damage via the downstream NF-κB-MMP-9 signaling pathway. Therefore, MST1 antagonists may serve as a novel therapeutic target to prevent early brain injury in SAH patients. PMID: 30018671 [PubMed - in process]
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
Abstract Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. Tetrahydrobiopterin (BH4) is an essential cofactor of NOS activity. Herein, we evaluated antiapoptotic and anti-inflammatory effects of diamino-6-hydroxypyrimidine (DAHP), a guanosine 5'-triphosphate cyclohydrolase 1 (GTPCH1) inhibitor on focal cerebral ischemia-reperfusion injury by middle cerebral artery occlusion and reperfusion (MCAO) and investigated the underlying mechanism. Sprague-Dawley rats were divided into five groups. Exper...
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
The average adult eats about 3,400 milligrams (mg) of sodium per day — far more than the recommended daily goal of 2,300 mg. Here are the top 10 types of food that account for more than 40% of the sodium we eat each day, along with some ideas for simple swaps to help you eat less salt. 1. Breads and rolls This category tops the list not because bread is especially salty (a slice contains about 100 to 200 mg of sodium), but because we eat so much of it. Smart swaps: Instead of toast or a bagel for breakfast, have a bowl of oatmeal prepared with just a pinch of salt. Bypass the dinner breadbasket for a serving of whole...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Eating Heart Health Hypertension and Stroke Source Type: blogs
Publication date: Available online 19 July 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Xiaoyan Zhu, Magalie Fréchou, Michael Schumacher, Rachida GuennounABSTRACTTreatment with progesterone limits brain damage after stroke. However, the cellular bases of the cerebroprotective effects of progesterone are not well documented. The aims of this study were to determine neural cells and functions that are affected by progesterone treatment and the role of neural progesterone receptors (PR) after stroke. Adult male PRNesCre mice, selectively lacking PR in the central nervous system, and t...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Carotid artery stenting (CAS) patients enrolled in the Nanjing Stroke Registry between December 2005 and November 2016.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Mean platelet volume may predict restenosis after carotid artery stenting and identify patients who may benefit from more intense antiplatelet therapy Source Type: research
Secondary data analysis based on a nationwide statutory quality assurance database between 2012 and 2014 by the Institute for Applied Quality Improvement and Research in Health Care by the aQua Institute, G öttingen, Germany.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Carotid artery stenting early after symptoms is associated with high risk of periprocedural  stroke Source Type: research
Objective measures of plaque area and tissue composition from duplex ultrasound (DUS) images may be useful for the risk stratification of patients with a greater likelihood of future adverse events (stroke, transient ischemic attacks, or amaurosis fugax) and to assess the effect of vascular risk factor modification strategies (by measuring change in overall plaque burden and/or individual plaque tissue constituents). Clinical assessment of carotid artery plaques is most commonly performed with two-dimensional DUS imaging.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2018 Eastern Vascular Society Annual Meeting Source Type: research
The objective of this study was to evaluate the technique and outcomes of this hybrid procedure at a single institution.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2018 Eastern Vascular Society Annual Meeting Source Type: research
I am pleased Ross Naylor is of the opinion that I have built a convincing case with respect to the implications of increasing stenosis severity in asymptomatic patients with carotid stenosis. Furthermore, it is difficult to refute the statement that carotid interventions are not undertaken to prevent transient ischemic attack (TIA). Virtually all natural history studies (Asymptomatic Carotid Stenosis and Risk of Stroke [ACSRS], North American Symptomatic Carotid Endarterectomy Trial [NASCET]) including ours (see Conrad, reference 3) have indicated that the index neurologic event in previously asymptomatic patients is as li...
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
The search for etiology of stroke in a young patient may present a diagnostic challenge. In rare cases, chronic external trauma to the carotid may be the cause of cerebral thromboembolic events. The hyoid bone lies in close proximity to the carotid artery bifurcation, and anatomic variants have been implicated in carotid compression, stenosis, dissection, and pseudoaneurysm.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts Presented to the Southern California Vascular Surgery Society Source Type: research
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