Updates on cardiovascular outcome trials in diabetes

In 2008 the Food and Drug Administration introduced a guidance for industry that requires the investigation of cardiovascular outcomes of glucose-lowering medications. Since then, an increasing number of cardi...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Review Source Type: research

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Authors: Wang P, Li X, He C, Zhai Y, Sun H, Zhang Y, Wang H, Wang Y, Zhao J, Tang Y Abstract OBJECTIVES: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status. METHODS: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. 340 (32.7%) had diabetes and 246 (23.6%) had HUA. Diabetic patients were stratified by gender or age. Multivariate logistic regression was used to analyse the association between HUA and pr...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Type 1 diabetes is the only chronic, life threatening disease where the dosing decisions of a potentially lethal hormone are left in the hands of the patient alone. There is technology that can catch errors quickly, but the costs fall on patients and their families.
Source: CBC | Health - Category: Consumer Health News Tags: News/Opinion Source Type: news
Authors: Ţânţu MM, Man GM, Rogozea LM, Domnariu CD, Pleşa FC, Traşcă DM, Cotoi BV, Stoica LE, Nicolae C, Nemeş RM Abstract Our study included a total of 259 patients with diabetes, who were admitted to the Department of Plastic Surgery and Reconstructive Microsurgery of the Emergency County Hospital of Piteşti, Romania, in 2016, with the diagnosis of "diabetic foot". Of the 259 patients, 55 (21.23%) were diagnosed with type 1 diabetes, and the remaining 204 (78.77%) were diagnosed with type 2 diabetes; the ratio of type 1∕type 2 diabetes was 1∕3.7. The injuries presented by the patients w...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Authors: Gherman D, Dumitrescu CI, Ciocan A, Melincovici CS Abstract Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. A key role is played by the loss of sensitive nerves, which prove to be a protective barrier against high pressure applied otherwise on the foot. The morphopathological characteristics of neuropathic lesions in patients with diabetes show important improveme...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Authors: Kalogirou M, Sinakos E Abstract Nonalcoholic fatty liver disease (NAFLD) is highly associated with insulin resistance (IR), type 2 diabetes mellitus and metabolic syndrome, being characterized as the hepatic component of metabolic syndrome. Despite its high prevalence, no pharmacological treatment has been established, as of yet. A growing body of evidence, however, shows that reducing IR can result in improvement of the biochemical and histological features of nonalcoholic steatohepatitis (NASH)-the aggressive form of NAFLD that can lead to cirrhosis and hepatocellular carcinoma. Unfortunately, the severa...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Authors: Gougelet A Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second cause of cancer-related death worldwide. The incidence of HCC is constantly increasing in correlation with the rise in diabetes and obesity, arguing for an urgent need for new developments in the treatment of this lethal cancer. Exosomes are small double-membrane vesicles loaded with distinct cargos, particularly small non-coding RNAs called microRNAs, representative of each donor cell and secreted to affect the features of neighboring cells or recipient cells located further away, like in the case of metastas...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
We read with interest the recent paper by Wei, Jih-Hua et al.1 Briefly, authors evaluated cardiovascular disease risk after metabolic surgery in 392 type 2 diabetes mellitus patients using UKPDS score and investigated the efficacy of different bariatric/metabolic procedures on cardiovascular disease risk reduction.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation. PMID: 30531693 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Diabetes is a major global health priority, affecting more than four hundred million adults worldwide [1]. The prevalence of the disease has been rising steadily, and it is predicted that almost 600 million people will be affected by 2035 [2]. More than 90% of diabetic patients suffer from type 2 diabetes, which is associated with macrovascular and microvascular complications and poses a significant burden on healthcare systems [3]. Type 2 diabetes is also increasingly affecting an alarming number of children, adolescents and young adults [2,4].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Review Source Type: research
Pancreatic cancer is one of the most common cancers worldwide, with a 5-year survival rate of approximately 7%, and for most patients, death occurs within 6months after the diagnosis [1]. As in most other countries, the health burden of pancreatic cancer in China is on the rise, with annual mortality rates nearly equal to the incidence [2]. According to GLOBOCAN 2012 [3], it was estimated that China accounted for 19.5% (65727/337872) of all newly diagnosed pancreatic cancer cases and 19.3% (63662/330391) of all deaths from pancreatic cancer worldwide.
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
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