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Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys.

Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys. Brain Res. 2017 Oct 07;: Authors: Zhang R, Andersen AH, Hardy PA, Forman E, Evans A, Ai Y, Yue J, Yue G, Gash DM, Grondin R, Zhang Z Abstract Acupuncture has increasingly been used as an alternative therapy for treatment of Parkinson's disease (PD). However, the efficacy of acupunture for PD still remains unclear. The present study was designed to objectively and safely monitor anti-parkinsonian effects of electroacupuncture (EA) and brain activity in nonhuman primates modeling human PD. Six middle-aged rhesus monkeys were extensively studied by a computerized behavioral testing battery and by pharmacological MRI (phMRI) scans with specific dopaminergic drug stimulations. All animals were evaluated for behavior and phMRI responses under normal, parkinsonian, parkinsonian with EA treatment and parkinsonian after EA treatment conditions. Stable parkinsonian features were observed in all animals prior to entering the EA study and positive responses to levodopa (L-dopa) challenge were also seen in all animals. The results demonstrated that chronic EA treatments could significantly improve the movement speed and the fine motor performance time during the period of EA treatments, and the effectiveness of EA could be detected even 3 months after the EA treatment. The phMRI data revealed that chronic EA treatments could alter neuronal activity in the striatum, primary motor cort...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

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Publication date: Available online 20 October 2017 Source:International Review of Neurobiology Author(s): Jose V. Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxea Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, but current therapies are only symptomatic. Experimental models are necessary to go deeper in the comprehension of pathophysiological mechanism and to assess new therapeutic strategies. The unilateral 6-hydroxydopamine (6-OHDA) lesion either in medial forebrain bundle (MFB) or into the striatum in rats affords to study various stages of PD depending on the evoluti...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Patients with increased levels of slow-wave, or deep, sleep show higher scores on cognitive assessments, a new study shows.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Conditions:   Continuous Rhythmic Auditory Stimulation;   Intermittent Rhythmic Auditory Stimulation Intervention:   Other: Rhythmic Auditory Stimulation (RAS) Sponsors:   University of Toronto;   Poudre Valley Health System Fort Collins CO;   Colorado State University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Heese K Abstract In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, thi...
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
Freezing of gait (FoG) is common in Parkinsonian gait and strongly relates to falls. Current clinical FoG assessments are patients’ self-report diaries and experts’ manual video analysis. Both are subjective and yield moderate reliability. Existing detection algorithms have been predominantly designed in subject-dependent settings. In this paper, we aim to develop an automated FoG detector for subject independent. After extracting highly relevant features, we apply anomaly detection techniques to detect FoG events. Specifically, feature selection is performed using correlation and clusterability metrics. From a...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Authors: Geroin C, Squintani G, Morini A, Donato F, Smania N, Gandolfi MG, Tamburin S, Fasano A, Tinazzi M Abstract Patients with Parkinson's disease (PD) and Pisa syndrome (PS) may present tonic dystonic or compensatory (i.e. acting against gravity) hyperactivity in the paraspinal and non-paraspinal muscles. Electromyographic (EMG) activity was measured in nine patients with PD and PS, three with PD without PS, and five healthy controls. Fine-wire intramuscular electrodes were inserted bilaterally into the iliocostalis lumborum (ICL), iliocostalis thoracis (ICT), gluteus medius (GM), and external oblique (EO) musc...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
Authors: Crosta F, Desideri G, Marini C Abstract An association of obstructive sleep apnea syndrome (OSAS) and other sleep-disordered breathing (SDB) with Parkinson's disease (PD) has been reported in some small studies. In the present study we investigated the occurrence of SDB in a large consecutive outpatient series. This is a case-control study in subjects attending a neurological clinic where all patients were screened for SDB by means of sleep-wake history, Epworth Sleepiness Scale, and full-night polysomnography, when indicated. 3194 patients were recruited. Of these, 194 were affected by PD and 77 by other ...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
ConclusionThe Theory of Planned Behaviour served as an effective framework for identifying the strong influence referents had on nursing staff intentions around managing residents with deteriorating health. Although nursing staff had a reasonable sense of control over this area of their work, they believed they benefitted from a hospital avoidance program initiated by the nursing home.This article is protected by copyright. All rights reserved.
Source: Journal of Clinical Nursing - Category: Nursing Authors: Tags: Original Article Source Type: research
Adaptive postural control is essential for almost all aspects of every day life. Impaired postural control results in substantial functional limitations in advanced age (Maki and McIlroy, 1996) and in pathological ageing conditions like stroke (Beyaert et al., 2015), Parkinson ’s disease (Schoneburg et al., 2013) or multiple sclerosis (Huisinga et al., 2012). Although rehabilitation and conditioning programs have shown promising results in recovery of postural control, those interventions are typically time and cost intensive and may only yield moderate effects (Howard- Wilsher et al., 2016; Smania et al., 2011; Yita...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
ConclusionsThe quality of appraised guidelines was low. It is necessary to improve the quality of guidelines on dystonia; the applied terminology of dystonia also needs to be standardized.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
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