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Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

Hamidreza Jamaati, Esmaeil Mortaz, Zeinab Pajouhi, Gert Folkerts, Mehrnaz Movassaghi, Milad Moloudizargari, Ian M. Adcock, Johan Garssen
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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ConclusionOur experience further highlights the challenges of LTBI screening prior to LT and suggests that QFT may be a poor predictor of active TB in higher risk pre‐transplant populations. Candidates should be screened as early as possible to optimize QFT performance, and local epidemiological data should be used to create institution‐specific screening protocols in areas with large populations from TB‐endemic regions. Management should consider TB risk factors, QFT, and imaging instead of reliance on QFT testing alone.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: The proportion of aboriginal population may play an essential role in determining Taiwan's population health. When universal health coverage is in place, the root causes (for example, alcoholism, culture, and socioeconomic disadvantages) of health disparities between aboriginal populations and general populations need to be addressed. PMID: 29450053 [PubMed - in process]
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
ro MG Abstract Although the tuberculin test represents the main in vivo diagnostic method used in the control and eradication of bovine tuberculosis, few studies have focused on the identification of mycobacteria in the milk from cows positive to the tuberculin test. The aim of this study was to identify Mycobacterium species in milk samples from cows positive to the comparative intradermal test. Milk samples from 142 cows positive to the comparative intradermal test carried out in 4,766 animals were aseptically collected, cultivated on Lowenstein-Jensen and Stonebrink media and incubated for up to 90 days. Coloni...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Authors: Khattak I, Mushtaq MH, Ayaz S, Ali S, Sheed A, Muhammad J, Sohail ML, Amanullah H, Ahmad I, Ur Rahman S Abstract Prevalence of zoonotic Mycobacterium bovis (bTB) disease in human population is underreported from the North of Pakistan. Here, we report on the proportion of human bTB disease among the overall TB patients, drug resistance pattern of bTB isolates, and knowledge, attitude, and practices (KAP)-based analysis of bTB disease. For this purpose, sputum samples from a total of 300 clinically diagnosed TB patients and 100 randomly selected school children suspected of pulmonary TB were processed by cul...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 17 February 2018 Source:Microbial Pathogenesis Author(s): Xin Li, Jiajia He, Weizhe Fu, Pingping Cao, Siyi Zhang, Tao Jiang Mycobacterium tuberculosis Rv3717 has been identified as a zinc-dependent amidase which can hydrolyze peptidoglycan (PG). To demonstrate the relationship of Rv3717 and cell division, in this study, Rv3717 gene was first amplified and expressed and the resulting protein was purified by using a His-tagged approach. M. smegmatis mc2155, a fast-growing and nonpathogenic mycobacterium was used to evaluate the effect of Rv3717 on cell division. Scan electron microscope (S...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, we review the most recent advances in research into TB‐BM for the diagnosis of active TB, risk of TB development and treatment‐induced TB cure.
Source: Respirology - Category: Respiratory Medicine Authors: Tags: Invited Review Series: Tuberculosis Updates 2018 Source Type: research
Authors: Eiset AH, Wejse C Abstract An unprecedented rise in the number of asylum seekers and refugees was seen in Europe in 2015, and it seems that numbers are not going to be reduced considerably in 2016. Several studies have tried to estimate risk of infectious diseases associated with migration but only very rarely these studies make a distinction on reason for migration. In these studies, workers, students, and refugees who have moved to a foreign country are all taken to have the same disease epidemiology. A common disease epidemiology across very different migrant groups is unlikely, so in this review of inf...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
Diagnosis of latent tuberculosis in individuals with recent exposure: tuberculin skin test versus interferon-γ release assay. Br J Biomed Sci. 2014 Jan;71(3):125-126 Authors: Reza Shokrollahi M, Noorbaksh S, Nasehi L, Movahedi Z PMID: 29443689 [PubMed]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Diagnosis of Latent Tuberculosis Infection Among Immunodeficient Individuals: Review of Concordance Between Interferon-γ Release Assays and the Tuberculin Skin Test. Br J Biomed Sci. 2014 Jan;71(3):115-124 Authors: Mamishr S, Pourakbari B, Marjani M, Mahmoudi S Abstract Mycobacterium tuberculosis remains as a major threat to global health. Nearly a third of the world's population is estimated to have latent M. tuberculosis infection, and this is considered to be a major reservoir of potential active disease. Immunocompromised individuals, such as those with chronic renal failure requiring haemodi...
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Previously unknown conjugates of the diterpenoid isosteviol1 and 1-O-methyl-2,3-di-O-acetyl- β-Darabinofuranoside in which the terpenoid and carbohydrate molecules were linked through polymethylene spacers of various lengths were synthesized. Isosteviol1 and its conjugate10 exhibited high bacteriostatic activity selectively against Staphylococcus aureus ATCC 209p. Conjugates9–11 inhibited growth of Mycobacterium tuberculosis H37Rv at the level of the antituberculosis drug pyrazinamide. Removal of the acetyl protection from conjugate9 increased the antituberculosis activity by eight times.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
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