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Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

Hamidreza Jamaati, Esmaeil Mortaz, Zeinab Pajouhi, Gert Folkerts, Mehrnaz Movassaghi, Milad Moloudizargari, Ian M. Adcock, Johan Garssen
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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The appointment of a new Executive Director to lead the Global Fund to Fight AIDS, Tuberculosis, and Malaria was not a tidy process. The first attempt to find a successor to Mark Dybul ended in ignominious failure, with questions raised, variously, about the moral probity and conflicts of interest of several prominent candidates. The Global Fund Board tried again. Four names made it through to the final shortlist. And then disaster seemed to strike once more. One candidate, Peter Sands, withdrew his name for “personal reasons”.
Source: LANCET - Category: General Medicine Authors: Tags: Comment Source Type: research
Pericardial fremitus – palpable pericardial rub A palpable pericardial rub is known as pericardial fremitus. It is due to the friction between the parietal and visceral layers of the pericardium. Some authors use the term as synonymous with pericardial rub [1,2]. Reference Miltgen J et al. Two Cases of Pulmonary Tuberculosis Caused by Mycobacterium tuberculosis subsp. canetti. Emerg Infect Dis. 2002 Nov; 8(11): 1350–1352. Box CR et al. Statistics of Pericarditis with Effusion, from the London Hospitals (St. Thomas’s). Proc R Soc Med. 1910; 3(Med Sect): 104–109.  
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
Abstract Establishment of infection by facultative intracellular pathogen Mycobacterium tuberculosis (Mtb) requires adherence to and internalisation by macrophages. However, the effector molecules exploited by Mtb for entry into macrophages remain to be fully understood. The mammalian cell entry (Mce) proteins play an essential role in facilitating the internalisation of mycobacteria into mammalian cells. Here, we characterized Mtb Mce3C as a new mycobacterial surface protein that could promote mycobacterial adhesion to and invasion of macrophages in an RGD motif‐dependent manner. We then further demonstrated that β...
Source: Cellular Microbiology - Category: Microbiology Authors: Tags: RESEARCH ARTICLE Source Type: research
Pugazhenthan Thangaraju, Sajitha Venkatesan, Elavarasan Sivashanmugam, MK Showkath AliIndian Journal of Dermatology 2017 62(6):563-563
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
AbstractTuberculosis (TB) is a crucial public health problem with prevalence of multidrug resistant (MDR) rising. An accurate TB biomarker is urgently needed to monitor the response to treatment in patients with MDR tuberculosis. To analyze interaction between selected MDR-TB purified protein and immune cells, dendritic cells from MDR-TB patients and healthy subjects were stimulated by 55KDa protein fractions (Rv0147). The purified proteins identified by proteomic techniques (two-dimensional gel electrophoresis, mass spectrometry) and peptide sequences are known to bind a MHC class I alleles which are extracted from the Im...
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
Publication date: Available online 24 November 2017 Source:Small Ruminant Research Author(s): Enric Vidal, Miriam Grasa, Tania Perálvarez, Maite Martín, Irene Mercader, Bernat Pérez de Val Increasing number of caprine tuberculosis (TB) reports grant the consideration of this zoonosis as an emerging disease that can play a role in the epidemiology of bovine TB in endemic areas. An outbreak of TB was detected in a caprine/ovine dairy mixed herd. Tuberculin skin test positive goats and ewes were euthanized and subsequent postmortem investigations were performed. Mycobacterium caprae (spoligotype profile ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
ConclusionThe addition of MGIT 960 culture medium to routine battery of investigations in infertility patients significantly improves the diagnosis.
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
My attention was drawn today to a recently published presentation by James Peyer. He heads up Apollo Ventures, one of the new crop of investment concerns focused on funding companies that are developing means to treat aging. These include the Longevity Fund, first out of the gate some years ago, as well as Juvenescence and the Methuselah Fund, created this year, and a repurposing of existing funds, such as Michael Greve's Kizoo ventures. Apollo Ventures is the source of the Geroscience online magazine that helps to advance and explain the position taken on aging by this group; this is something that more investors should d...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Authors: Martini M, Barberis I, Bragazzi NL, Paluan F Abstract The second half of the nineteenth century saw the development of new medical "specialties", which, like the idea of constitutional disease, had a profound influence on medical practice. Against this lively "backdrop", Edoardo Maragliano played a central role in medicine's "renaissance" in Italy. Having graduated in medicine in 1870 at the University of Naples, he worked as an assistant in the University Medical Clinic. After beginning his academic career as professor of pathology at the Faculty of Medicine in Genoa in 1877,...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Christophe J. Queval, Roland Brosch, Roxane Simeone
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
More News: Microbiology | Tuberculosis