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Activation of a Neospora caninum EGFR-Like Kinase Facilitates Intracellular Parasite Proliferation

Xiaoxia Jin, Guojiang Li, Xichen Zhang, Pengtao Gong, Yanhui Yu, Jianhua Li
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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AbstractWe evaluated, for the first time, the leishmanicidal potential of decanethiol functionalized silver nanoparticles (AgNps –SCH) on promastigotes and amastigotes of different strains and species ofLeishmania: L. mexicana andL. major isolated from different patients suffering from localized cutaneous leishmaniasis (CL) andL. mexicana isolated from a patient suffering from diffuse cutaneous leishmaniasis (DCL). We recorded the kinetics of promastigote growth by daily parasite counting for 5 days, promastigote mobility, parasite reproduction by CFSE staining ’s protocol and promastigote killing using the pro...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
Authors: Yakoob J, Abbas Z, Khan R, Tariq K, Awan S, Beg MA Abstract Introduction An association of Helicobacter pylori and common protozoal parasites in patients with abdominal discomfort and chronic diarrhoea is unclear and may be pathological. Materials and methods One hundred and sixty-one patients with diarrhoea were compared to 114 age and sex matched controls. Stool samples were examined by microscopy and DNA extracted for PCR with specific primers for H. pylori and protozoal parasites Blastocystis sp., Entamoeba sp. (Entamoeba histolytica, Entamoeba dispar and Entamoeba moshkovskii) and Giardia duodenalis (...
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
This study reports a rare clinical case of primary mucosal leishmaniasis on the lip that had a delayed diagnosis, highlighting the precariousness in the management of disease and showing that, despite the importance of leishmaniasis in Brazil, it is still neglected by health professionals. PMID: 29451600 [PubMed - in process]
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Abstract Leishmaniasis is a worldwide tropical infectious disease caused by different species of intracellular protozoa parasites of the genus Leishmania . Herein, we report a 78-year-old man with unusual diffuse cutaneous leishmaniasis (DCL) who had a history of opium abuse and chronic obstructive pulmonary disease (COPD). He had multiple papular, crusted and severely ulcerated lesions extended to his arm and chest. Direct smears and skin punch biopsy of the lesions were suggestive of leishmaniasis. Parasite DNA was amplified from ulcers, and identified as Leishmania major by PCR-RFLP, confirmed by sequencing ana...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
ia JS Abstract Angiostrongylus cantonensis is considered the main etiological agent of eosinophilic meningitis in humans. At present, this zoonosis is considered an emerging disease mainly in the Americas. The aim of this study was to determine the prevalence of Achatina fulica infected by Angiostrongylus cantonensis in restinga areas along beaches in the west zone of Rio de Janeiro city, Brazil. The study areas included the following beaches: Barra da Tijuca, Recreio dos Bandeirantes, Reserva, Prainha and Grumari. Ninety specimens of Achatina fulica were collected. Positive molluscs were found only in Barra da Ti...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama. We analyzed 49 skin biopsy samples from patients with clinical suspicion of CL, by molecular tests (PCR for subgenus Viannia and HSP-70) and by Hematoxylin-Eosin staining. Samples were characterized at the species level by PCR-HSP-70/RFLP. From the 49 samples studied, 46 (94%) were positive by PCR and were characterized as Leishmania (V.) panamensis. Of these, 48% were positive by Hematoxylin-Eosin staining with alterations being observed both, in the epidermis (85%) and i...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Authors: Cesinaro AM, Nosseir S, Mataca E, Mengoli MC, Cavatorta C, Gennari W Abstract Canine Leishmaniasis is a disease endemic in many parts of Europe, carried by insects of phlebotomous species. Humans are occasional hosts of the parasites. Cases of human leishmaniasis have been registered in Italy, particularly in the southern and coastal regions. In the period 1997-2016, we collected a series of 35 patients affected by cutaneous leishmaniasis, uncovered by skin biopsy and histological examination, 21 of them found in last 3 years. The patients, 28 males and 7 female, aged between 19 and 91, resided in a restri...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
Publication date: Available online 17 February 2018 Source:Microbial Pathogenesis Author(s): Kun Li, Jinhuan Jiang, Muhammad Shahzad, Hui Zhang, Khalid Mehmood, Xiong Jiang, Xiaodong Zhao, Houqiang Luo, Xiaole Tong, Jiakui Li Diarrhea a serious disease, reported to be related with changes in microbial diversity is widely epidemic in the yaks on the Qinghai Tibet plateau. Herein, we preformed high-throughput sequencing of the parasitic diversity in 3 groups of yaks i.e. healthy adult yaks (HA), diarrheic adult yaks (DA) and diarrheic yak calves (DC) in Gannan Tibetan Autonomous Prefecture. The results showed that 2 Phyla, ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: 1 May 2018 Source:Inorganica Chimica Acta, Volume 476 Author(s): Sidra Sarwar, Tuba Iftikhar, Muhammad Khawar Rauf, Amin Badshah, Durdana Waseem, Muhammad Nawaz Tahir, Khalid Mohammed Khan, Gul Majid Khan In the search of new drugs with high therapeutic efficacy, antimony (V) dicarboxylates bearing cinnamate moieties with general formula [SbR3(O2CR′)2] have been synthesized and characterized by spectroscopic techniques like FTIR, multinuclear (1H and 13C) NMR and single crystal X-ray diffraction. The organic moieties (R) in the complexes are phenyl and p-tolyl while the carboxylates are heterocycli...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
AbstractThe present study was designed to assess the deleterious effects of bovine tropical theileriosis on the cardiovascular system and the consequent myocardial involvement in young calves. Myocardial effects in parasitic diseases are often neglected. Hemolytic anemia, associated secondary hypoxia, and vasculitis are cardinal features of bovine theileriosis. In the present study, electrocardiogram (ECG) alongside serum cardiac troponin I (cTnI) and creatinine phosphokinase-myocardial band (CPK-MB) concentrations were analyzed in infected, treated, and control groups of young calves. Non-significant alterations were noti...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
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