Acinetobacter baumannii Virulence Traits: A Comparative Study of a Novel Sequence Type with Other Italian Endemic International Clones

Cecilia Ambrosi, Daniela Scribano, Marta Aleandri, Carlo Zagaglia, Laura Di Francesco, Lorenza Putignani, Anna Teresa Palamara
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

Related Links:

Abstract Acinetobacter baumannii is one of the highly antibiotic-resistant bacteria that cause infections with high rate of death. This bacterium is one the common causes of infection worldwide leading to endemic and epidemic nosocomial infections. Despite many efforts, there is no effective vaccine against A. baumannii. As NlpA is one of the important antigenic factors in biogenesis of outer membrane vesicles, and OMV-based reported vaccines in A. baumannii stimulated the immune responses, this study was aimed to clone and express nlpA gene in eukaryotic HDF cells and evaluate the induced immunization following t...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
Acinetobacter baumannii has become a troublesome emerging pathogen because of its wide range of resistance determinants and its environmental resilience [1]. It is responsible for severe nosocomial infections in intensive care unit (ICU) patients, mainly ventilator associated pneumonia, bacteremia, and central nervous system infections [2,3]. Most of A. baumannii strains are multidrug-resistant (MDR) [1] and have become endemic in several healthcare environments, often causing sustained outbreaks.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
Acinetobacter baumannii origin and its epidemiology is under a great concern worldwide since this microorganism has become a leading nosocomial pathogen of the 21th century among the " ESKAPE " group of microorganisms. The aim of the study was to monitor and explore the epidemiology of this important hospital pathogen in the second largest clinical university hospital in Croatia. The presence ofA. baumannii in hospital wastewater, as a route for possible transmission outside of the hospital setting, as well as its survival in environmental conditions including seawater, was investigated. During the examination pe...
Source: International Microbiology - Category: Microbiology Source Type: research
Acinetobacter baumannii origin and its epidemiology is under a great concern worldwide since this microorganism has become a leading nosocomial pathogen of the 21th century among the " ESKAPE " group of microorganisms. The aim of the study was to monitor and explore the epidemiology of this important hospital pathogen in the second largest clinical university hospital in Croatia. The presence ofA. baumannii in hospital wastewater, as a route for possible transmission outside of the hospital setting, as well as its survival in environmental conditions including seawater, was investigated. During the examination pe...
Source: International Microbiology - Category: Microbiology Source Type: research
Authors: Rodríguez CH, Nastro M, Famiglietti A Abstract Carbapenem resistance in gram-negative bacteria by production of carbapenemases is one of the most challenging issues regarding healthcare worldwide. We review the epidemiology and prevalence of carbapenemases in carbapenem-resistant Acinetobacter baumannii isolates from Latin American countries. High resistance rates to antimicrobial agents, particularly to carbapenems, are observed in this region. OXA-23 is the most widely disseminated class D-carbapenemase; it is present in all the countries of the region and is frequently associated to endemic clone...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
ConclusionsCarbapenem-nonsusceptibleA. baumannii-calcoaceticus complex are endemic in this setting. Prevention requires source control and limiting transmission of strains.Trial registrationThe study was retrospectively registered atwww.trialregister.nl (No:5541). Candidate number: 23,527, NTR number: NTR5541, Date registered NTR: 22nd December 2015.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
Conclusions These results indicate that the surveillance program implemented was effective in preventing the spread of multidrug-resistant organisms in the hospital.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 September 2017 Source:Medicina Intensiva (English Edition) Author(s): D. Escudero, L. Cofiño, L. Forcelledo, B. Quindós, C. Calleja, L. Martín
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
AbstractWe evaluated an infection control (IC) program influenced by personnel and material resource shortages on the incidence of bloodstream infections (BSI) due to carbapenem-resistantKlebsiella pneumoniae (CRKP),Acinetobacter baumannii (CRAB), andPseudomonas aeruginosa (CRPA) in an endemic region. Between January 2010 and December 2015, all BSI episodes caused by CRKP, CRAB, and CRPA were recorded. An IC bundle was implemented in January 2012. We evaluated the effect of the interventions on BSI rates between the pre-intervention (2010 –2011) and intervention (2012–2013) periods, using an interrupted time-se...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
In this study, we applied three easier, faster, and cost-effective methods including PCR-based open reading frames (ORFs) typing, sequence typing of blaOXA-51-like and RAPD-PCR method to rapid typing of A. baumannii strains. Taken together in the present study the results of ORFs typing, PCR-sequencing of blaOXA-51-like genes and MLST sequence typing revealed there was a high prevalence (62%, 35/57) of ST2 as international and successful clone which detected among clinical isolates of multi-drug resistant A. baumannii with ORF pattern B and blaOXA-66 gene. Only 7% (4/57) of MDR isolates belonged to ST1 with ORF pattern A a...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
More News: Acinetobacter | Endemics | Italy Health | Microbiology | Study