Coordinated morphogenesis of neurons and glia.

Coordinated morphogenesis of neurons and glia.
Curr Opin Neurobiol. 2017 Oct 05;47:58-64
Authors: Lamkin ER, Heiman MG
Abstract
Glia adopt remarkable shapes that are tightly coordinated with the morphologies of their neuronal partners. To achieve these precise shapes, glia and neurons exhibit coordinated morphological changes on the time scale of minutes and on size scales ranging from nanometers to hundreds of microns. Here, we review recent studies that reveal the highly dynamic, localized morphological changes of mammalian neuron-glia contacts. We then explore the power of Drosophila and C. elegans models to study coordinated changes at defined neuron-glia contacts, highlighting the use of innovative genetic and imaging tools to uncover the molecular mechanisms responsible for coordinated morphogenesis of neurons and glia.
PMID: 28988011 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - October 5, 2017 Category: Neurology Authors: Lamkin ER, Heiman MG Tags: Curr Opin Neurobiol Source Type: research