Premonitory urges and tics in Tourette syndrome: computational mechanisms and neural correlates.
Premonitory urges and tics in Tourette syndrome: computational mechanisms and neural correlates.
Curr Opin Neurobiol. 2017 Oct 06;46:187-199
Authors: Conceição VA, Dias Â, Farinha AC, Maia TV
Abstract
Tourette syndrome is characterized by open motor behaviors - tics - but another crucial aspect of the disorder is the presence of premonitory urges: uncomfortable sensations that typically precede tics and are temporarily alleviated by tics. We review the evidence implicating the somatosensory cortices and the insula in premonitory urges and the motor cortico-basal ganglia-thalamo-cortical loop in tics. We consider how these regions interact during tic execution, suggesting that the insula plays an important role as a nexus linking the sensory and emotional character of premonitory urges with their translation into tics. We also consider how these regions interact during tic learning, integrating the neural evidence with a computational perspective on how premonitory-urge alleviation reinforces tics.
PMID: 29017141 [PubMed - as supplied by publisher]
Source: Current Opinion in Neurobiology - Category: Neurology Authors: Conceição VA, Dias Â, Farinha AC, Maia TV Tags: Curr Opin Neurobiol Source Type: research
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