Arginine Modification of Lycosin-I to Improve Inhibitory Activity Against Cancer Cells.

Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02233F, PaperPeng Zhang, Jing Ma, Yujie Yan, Bo Chen, Bobo Liu, Cui Jian, Baode Zhu, Song ping Liang, Youlin Zeng, Zhonghua Liu Lycosin-I is a linear amphipathic [small alpha]-helical anticancer peptide (ACP) extracted from the spider Lycosa singoriensis, which can activate the mitochondrial death pathway to induce apoptosis in tumor cells and up-regulate... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research

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In this study, a simple but sensitive electrochemiluminescence (ECL) biosensor has been designed for HAase detection based on the electrostatic interaction of anionic hyaluronic acid (HA) and cationic luminous reagent Ru(bpy)32+. Ru(bpy)32+ is adsorbed on HA through electrostatic interaction to form HA-Ru(bpy)32+ complex. The Ru(bpy)32+ in the HA-Ru(bpy)32+ complex cannot be filtered out because of its large molecular weight. In the presence of HAase, the HA in HA-Ru(bpy)32+ can be cleaved into fragments by enzymatic hydrolysis. As a result, the Ru(bpy)32+ attached on the HA fragments can be separated from the HA-Ru(bpy)32...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: 1 November 2018Source: Inorganica Chimica Acta, Volume 483Author(s): Yeşim Salman, Fırat Barış Barlas, Murat Yavuz, Kerem Kaya, Suna Timur, Fatma Çetin TelliAbstractFour novel dinuclear Cu(II) complexes (1a–4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1–4). All the new complexes (1a–4a) have been characterized by Fourier transform infrared spectroscopy, UV–visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this comp...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Reese Witherspoon and Keith Urban are among the stars joining the sixth Stand Up To Cancer telethon on Sept. 7.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
BOWEL cancer risk could be reduced by making some diet or exercise changes. Eating more of this cheap vegetable could prevent the deadly disease, scientists have claimed. Its preventative effects are “striking”, they said.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
To outwit cancer, researchers are working on better ways to teach patients' immune system to root out and kill malignant cells. A promising approach involves cells that attack cancer two ways at once.(Image credit: Pearl Mak/NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
This study examines whether cancers that are classified as HER2-amplified with an alternate probe are clinicopathologically similar to those that are classified as such using the HER2/CEP17 probe. Reports for 1201 breast cancers were reviewed, and clinicopathologic findings were compared between HER2/CEP17-equivocal cases that became HER2-amplified using the alternate probe (group A: n=48), HER2-amplified cases using the HER2/CEP17 probe (group B: n=169), and HER2-nonamplified cases using the HER2/CEP17 probe (group C: n=910). Of 1201 cases tested using the HER2/CEP17 probe, 169 (14%) were HER2-amplified, 122 (10%) were eq...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
The immune regulatory enzyme indoleamine-2,3-dioxygenase (IDO-1) suppresses T cell responses and may reduce efficacy of therapies targeting immune checkpoints such as programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1). Early phase clinical trials combining IDO-1 and PD-1/PD-L1 inhibitors have shown some promise in non–small cell lung cancers (NSCLCs). However, the coexpression of IDO-1 and PD-L1 has not been thoroughly investigated, and the potential for IDO-1 immunohistochemical expression as a therapeutic biomarker is unknown. One hundred two cases of NSCLC (51 adenocarcinomas, 9 adenosquamous carci...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Staging criteria for renal cell carcinoma differ from many other cancers, in that renal tumors are often spherical with subtle, finger-like extensions into veins, renal sinus, or perinephric tissue. We sought to study interobserver agreement in pathologic stage categories for challenging cases. An online survey was circulated to urologic pathologists interested in kidney tumors, yielding 89% response (31/35). Most questions included 1 to 4 images, focusing on: vascular and renal sinus invasion (n=24), perinephric invasion (n=9), and gross pathology/specimen handling (n=17). Responses were collapsed for analysis into positi...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
We present a well-applicable and accurate tool to predict which breast cancer patients may have an underlying BRCA germline mutation, largely consisting of immunohistochemical markers independent of clinical characteristics. This may improve identification of potential BRCA germline mutation carriers and optimize referral for germline mutation testing.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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