Electrophilic and nucleophilic addition reactions of Ir(1-2,5- η-CH2CHCHCHSO2)(PMe3)3 with HBF4, acetonitrile, CO, pyridine and methanol: Haptotropic behavior of the butadienesulfonyl ligand
Publication date: 1 December 2017 Source:Journal of Organometallic Chemistry, Volume 852 Author(s): Marisol Cervantes-Vásquez, Antonio A. Castillo-García, Naytzé Ortiz-Pastrana, M. Angeles Paz-Sandoval Reaction of IrCl(PMe3)3 with one equivalent of K(SO2CHCHCHCH2) led to the formation of Ir(1-2,5-η-CH2CHCHCHSO2)(PMe3)3 (1). The reaction of 1 with HBF4⋅Et2O takes place rapidly at low temperature to give the metallacycle [Ir(2,5-η-MeCHCHCHSO2)(PMe3)3]BF4 (2). Complex 2 reacts with CH3CN, CD3CN and CO to give the corresponding adducts [Ir(2,5-η-MeCHCHCHSO2)(PMe3)3(L)]BF4 (L = CH3CN, 3; CD3CN, 3D; CO, 4). Interestingly, compound 2 in the presence of pyridine or deuterated pyridine isomerizes to the terminal allyl compound [Ir(1-3,5-η-CH2CHCHCH2SO2)(PMe3)3]BF4 (5), while in the presence of oxygenated solvents, such as methanol, acetone and water, or their corresponding deuterated solvents, affords a mixture of cationic internal allyl isomers [Ir(2-4,6-η-MeCHCHCHSO2)(PMe3)3]BF4 (6a) and [Ir(2-4,5-η-MeCHCHCHSO2)(PMe3)3]BF4 (6b), being 6a always the major isomer. The iridium center is coordinated to an oxygen atom of the sulfone moiety in 6a, while for 6b coordination through the sulfur atom is proposed. Single-crystal X-ray diffraction studies of 5 and 6a confirm the unprecedented formation of novel sulfone-pentenyl ligands bonded to the iridium center through an η3 interaction and also by S and O coordination affordin...
DiscussionMCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
CONCLUSIONS: Local application of sevoflurane in the wound bed appears to exhibit analgesic, antimicrobial, and positive healing effects. It could be a promising alternative treatment to be included as a therapeutic option for wound care. PMID: 31730517 [PubMed - in process]
CONCLUSIONS: Cutaneous vasculopathy related to the skin, such as livedo reticularis and ulcers of torpid evolution due to cutaneous vasculopathy are extremely rare. Thus, it is necessary to include skin ulcers as one of the phenotypic manifestations of NF-1. PMID: 31730516 [PubMed - in process]
CONCLUSIONS: The authors suggest stasis mucinosis and OALM represent the spectrum of euthyroid mucin depositional disease in varying clinical settings. PMID: 31730515 [PubMed - in process]
CONCLUSIONS: From this case report, the authors believe NPWTi-d may be more effective in cases with intractable ulcers associated with infection that need better granulation. PMID: 31730514 [PubMed - in process]
Authors: Roshangar L, Soleimani Rad J, Kheirjou R, Reza Ranjkesh M, Ferdowsi Khosroshahi A Abstract Burn wounds are one of the main causes of skin damage. Based on World Health Organization statistics, almost 300 000 people worldwide die of burns each year. In severe burns, the cells and blood vessels are often injured and the blood supply to the wound is disturbed. Many factors such as oxygenation, infection, aging, hormones, and nutrition potentially can influence burn progression and disrupt repair with unbalanced release of various growth factors and cytokines. Different treatment approaches such as dressings a...
CONCLUSIONS: An illustrated guide for dressing application in burn wounds was developed and validated for content by an expert panel. PMID: 31730512 [PubMed - as supplied by publisher]
CONCLUSIONS: This is the largest cohort reported in the literature of patients with frostbite injuries treated with HBOT. Hyperbaric oxygen therapy may show positive impact on the demarcation level of frostbite and, despite the common side effects, it generally causes no long-term sequelae. PMID: 31730511 [PubMed - as supplied by publisher]
CONCLUSIONS: This is an easily reproducible and safe technique for effluent control in patients with Björk grade 4 abdomen with established EAF. PMID: 31730510 [PubMed - as supplied by publisher]
CONCLUSIONS: These results suggest the importance of arterial-arterial connections such as the pedal arch to the healing potential of foot and ankle wounds after STSG in this high-risk patient population. PMID: 31730509 [PubMed - as supplied by publisher]