Study of polymorphism in 2, 2 ′-diselenobis(3-pyridinol)

Publication date: 1 December 2017 Source:Journal of Organometallic Chemistry, Volume 852 Author(s): Prasad P. Phadnis, Amit Kunwar, Mukesh Kumar, Ratikanta Mishra, Amey Wadawale, K.I. Priyadarsini, Vimal K. Jain 2,2′-Diselenobis(3-pyridinol), [2-C5H3N(3-OH)Se]2 (DISPOL) (1) and 3-hydroxypyridine-2-(1H) selone (2) were synthesized and characterized by microanalyses, NMR (1H, 13C{1H}, and 77Se{1H}) spectroscopy. The 1 on recrystallization from various organic and aqueous solutions resulted in different polymorphs which were unambiguously characterized by single crystal X-ray diffraction analyses at room as well as low temperatures. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and differential thermal analysis (DTA) of 1 confirmed the existence of two polymorphs. The bulk 1 and its polymorphs exhibited potent cytotoxicity against A549 human lung carcinoma cells (IC50 values ≈ 10 μM). The compound is thermodynamically stable and is a promising candidate for further pharmacological studies as a cytotoxic agent. Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research