An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics.

CONCLUSIONS: The i.pl. HS assay is easily performed, rapidly detects standard analgesics, and produces minimal animal suffering without tissue damage. We propose this assay as a useful addition to the armamentarium of existing preclinical analgesic screens.
PMID: 28991111 [PubMed - as supplied by publisher]

Source: Anesthesia and Analgesia - October 5, 2017 Category: Anesthesiology Authors: Asiri YI, Fung T, Schwarz SKW, Asseri KA, Welch ID, Schuppli CA, Barr AM, Wall RA, Puil E, MacLeod BA Tags: Anesth Analg Source Type: research