Alcohol's Effects on the Cardiovascular System.
Alcohol's Effects on the Cardiovascular System. Alcohol Res. 2017;38(2):219-241 Authors: Piano MR Abstract Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are outlined in this review. Although many behavioral, genetic, and biologic variants influence the interconnection between alcohol use and CV disease, dose and pattern of alcohol consumption seem to modulate this most. Low-to-moderate alcohol use may mitigate certain mechanisms such as risk and hemostatic factors affecting atherosclerosis and inflammation, pathophysiologic processes integral to most CV disease. But any positive aspects of drinking must be weighed against serious physiological effects, including mitochondrial dysfunction and changes in circulation, inflammatory response, oxidative stress, and programmed cell death, as well as anatomical damage to the CV system, especially the heart itself. Both the negative and positive effects of alcohol use on particular CV conditions are presented here. The review concludes by suggesting several promising avenues for future research related to alcohol use and CV disease. These include using direct biomarkers of alcohol to confirm self-report of alcohol consumption levels; studying potential mediation of various genetic, socioeconomic, and racial and eth...
Conclusion: The knowledge about hypertension among majority of patients was reasonable. But they were unaware of their disease status. The drug compliance among them was poor. Forgetfulness and interruptions of daily routine were common reasons attributed for nonadherence. PMID: 29230325 [PubMed]
New J. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7NJ04008C, PaperSajjad Mohebbi, Parvin Askari A new nanohybrid catalyst by covalent linking of tetraacetate porphyrin cobalt(II) complex to TiO2/BiVO4 nanocomposite was synthesised and its photocatalytic efficiency toward alcohol oxidation under visible light irradiation monitored by... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7CC08548F, CommunicationLouis Lancaster, David P Hickey, Matthew S. Sigman, Shelley Minteer, Ian Wheeldon This work combines the thermostable alcohol dehydrogenase D (AdhD) from Pyrococcus furiosus and the organic electrocatalyst TEMPO to create a bifunctional catalyst that selectively oxidizes primary and secondary alcohols. The... The content of this RSS Feed (c) The Royal Society of Chemistry
Conclusions: In diabetic patients with NAFLD, light or moderate lifetime alcohol consumption was not significantly associated with liver fibrosis. The impact of lifetime alcohol intake on fibrosis progression and diabetic comorbidities, in particular obstructive sleep apnea and hypertriglyceridemia, requires further investigation. PMID: 29226116 [PubMed - in process]
The new ACC/AHA guidelines for hypertension lowered the threshold for a diagnosis of hypertension. Are these changes justified?Georgetown University Family Medicine
From PCP referral paperwork...Patient takes oxycodone 15 mg TID, works at gas station. Family hx of alcoholism. Single mom. Also has fibro. How do you appraise the providers medical decision making to refer a patient who declines pain management to a pain clinic? Is this patient-centered care with justifiable shared decision making? Would the patient attest to receiving "high value," quadruple aim care responsive to her personalized needs? What's your next move? View attachment 226579
CONCLUSION: Functional electrical stimulation and ankle foot orthoses have an equally positive therapeutic effect on walking speed in non-progressive central nervous system diagnoses. The current randomized controlled trial evidence base does not show whether this improvement translates into the user's own environment or reveal the mechanisms that achieve that change. Future studies should focus on measuring activity, muscle activity and gait kinematics. They should also report specific device details, capture sustained therapeutic effects and involve a variety of central nervous system diagnoses. PMID: 29227525 [PubMe...
Summary BackgroundRegional ventricular pumping mechanisms in patients with volume‐loaded right ventricles (RV) are altered, but the cause is unknown. The aim was to determine whether these changes in ventricular pumping mechanisms are influenced by the RV dilatation itself or the aetiology behind it. MethodsSeventeen patients with atrial septal defects (ASD) and 10 healthy controls underwent cardiovascular magnetic resonance (CMR) at rest and during dobutamine/atropine stress. Sixteen patients underwent transcutaneous ASD closure. Follow‐up CMR at rest was performed the following day. Thirty patients with RV overload d...
Authors: Bedendo A, Lucas Dos Santos E, Noto AR PMID: 29227244 [PubMed - in process]
CONCLUSIONS: Alcohol cue reactivity in heavy social drinkers was related to faster early attentional processes and motivational salience. The effect occurred independently of visual features in the pictures. PMID: 29227243 [PubMed - in process]