Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge

Author Affiliations open 1Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK 2Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK 3Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland 4Swansea University Medical School, Swansea, Wales, UK 5University of Rochester Medical Center, Rochester, New York 6Department of Public Health, University of Copenhagen, Copenhagen, Denmark 7IUF Leibniz-Institut für Umweltmedizinische Forschung, Düsseldorf, Germany 8National Research Centre for the Working Environment, Copenhagen, Denmark 9Department of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark 10Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Munich, Germany 11Air Quality &Sustainable Nanotechnology Unit, Institut für Energie- und Umwelttechnik e. V. (IUTA), Duisburg, Germany 12Federal Institute of Occupational Safety and Health, Duisburg, Germany 13Norwegian Institute of Public Health, Oslo, Norway 14Center for Environment and Health, Katholieke Universiteit Leuven, Leuven, Belgium 15Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy 16Departmento de Toxicología, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), México City, México 17Paris Diderot University, P...
Source: EHP Research - Category: Environmental Health Authors: Tags: Review Source Type: research

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This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves. The heliangolide sesquiterpene lactone was isolated through a combination of solvent-solvent partitioning, column chromatography, thin layer chromatography and high-performance liquid chromatography techniques. The antioxidant activity of the compound was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays while the antidiabetic effects were investigated in alloxan-induced diabetic rats. The heliangolide derivative at the concentratio...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Conclusion: The miniature electrode developed in this study successfully necrotized cells in a tissue phantom 400 μm deep from the surface with the electric pulses of only 20 V. Significance: The contact IRE for the surface of skin and gastrointestinal tract will ablate cutaneous and subcutaneous tumors by applying only several tens of volts.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: Regional electrophysiology and paths in the model match human action potentials, dynamic behavior, and cardiac activation sequences. Connected in closed loop with a pacing device in DDD mode, the model generates complex arrhythmia such as atrioventricular nodal reentry tachycardia. Such device-induced outcomes have been observed clinically and we can establish the key physiological features of the heart model that influence the device operation. Significance: These findings demonstrate how an abstract heart model can be used for device validation and to design personalized treatment.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Objective: Subcutaneous (sc) administration of long-acting insulin analogs is often employed in multiple daily injection (MDI) therapy of type 1 diabetes (T1D) to cover patient's basal insulin needs. Among these, insulin glargine 100 U/mL (Gla-100) and 300 U/mL (Gla-300) are formulations indicated for once daily sc administration in MDI therapy of T1D. A few semi-mechanistic models of sc absorption of insulin glargine have been proposed in the literature, but were not quantitatively assessed on a large dataset. The aim of this paper is to propose a model of sc absorption of insulin glargine able to describe the...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 21 January 2020Source: NeurocomputingAuthor(s): Emmanouil Giannakakis, Cheol E. Han, Bernd Weber, Frances Hutchings, Marcus KaiserAbstractSimulations of neural networks can be used to study the direct effect of internal or external changes on brain dynamics. However, some changes are not immediate but occur on the timescale of weeks, months, or years. Examples include effects of strokes, surgical tissue removal, or traumatic brain injury but also gradual changes during brain development. Simulating network activity over a long time, even for a small number of nodes, is a computational cha...
Source: Neurocomputing - Category: Neuroscience Source Type: research
CONCLUSIONS: The efficiency of passive and active transport of imipramine hydrochloride is influenced by the presence of Mg, Zn and Cu ions. The passive transport of imipramine hydrochloride after 90 minutes of experiment was the most effective in the presence of copper and zinc ions. Further studies conducted on the CaCo-2 cell line indicated a clear positive interaction of imipramine - zinc. PMID: 31955193 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: Patients with morbid obesity need health, nutritional, and psychological education. PMID: 31955190 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: SkowroĊ„ska A, Sójta K, Strzelecki D Abstract Refeeding syndrome (RS) is one of the serious complications during treatment of anorexia nervosa. It includes hormonal and metabolic changes that occur during the process of refeeding in chronically malnourished patient when nutrition is introduced in an excessive and improper amount. RS manifests in water-electrolyte imbalances, including hypophosphatemia (the mostimportant diagnosticmarker), hypokalemia, hyponatremia, hypomagnesaemia, fluid retention, vitamin deficiency and metabolic acidosis. It applies to either oral and parenteral supplementation. I...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: Polish version of the BISC can be considered comparable to the original measure. The BISC-PLmay be recommended as a useful tool to complement Polish research and practise. Results are discussed with regard to limitations of the current research and implications for future studies. PMID: 31955187 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
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