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Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques.

Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques. Mol Med Rep. 2017 Oct 03;: Authors: Liu T, Liu H, Feng L, Xiao B Abstract Stroke caused by atherosclerosis remains a leading cause of morbidity and mortality worldwide, associated with carotid plaque rupture and inflammation progression. However, the inflammatory biomarkers which aid in predicting the future course of plaques are less detailed. The present study investigated the association between plaque vulnerable and inflammatory biomarkers using blood and plaque specimens. Carotid plaque specimens were obtained from 80 patients following stroke, 14 patients suffering from transient ischaemic attack and 17 asymptomatic patients that underwent carotid endarterectomy. To assess changes in plaque characteristics at histological levels, plaques were categorized by the time between the latest ischemic stroke and surgical intervention within 30, 30‑90, 90‑180 and over 180 days following stroke. Serum levels of inflammatory biomarkers interleukin (IL)‑6, IL‑10 and kinin B1 receptor (B1R) were measured by ELISA. Histological assessment of plaque was used to evaluate the plaque stability, progression and the inflammatory biomarker levels. Comparisons of histological characteristics demonstrated that plaques revealed an unstable phenotype following stroke within 30, 30‑90 days and then remodeled into more stable plaques following stro...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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InspireMD (NYSE:NSPR) this week touted an independent clinical trial in Russia pitting its CGuard embolic protection device against the Rx Acculink carotid stent made by Abbott (NYSE:ABT). The 100-patient trial is designed to compare the two devices in terms of neuroprotection and clinical superiority in subjects undergoing carotid endarterectomy, the Tel Aviv-based company said. Conducted at the Scientific Research Institute of Circulation Pathology in Novosibirsk, the study is led by Dr. Andrei Karpenko. The primary endpoint is new ischemic areas in the brain 24 to 48 hours post-procedure and new lesi...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Stents InspireMD Stroke Source Type: news
Haemorrhagic stroke is a rare and vexing complication of carotid endarterectomy (CEA). It occurs some days after a successful operation to prevent further ischaemic strokes, usually in the setting of post-operative hypertension, headache, or the full clinical picture of hyperperfusion syndrome, which features seizures, and cognitive and vigilance disturbances. The major risk factor associated with the hyperperfusion syndrome and intracerebral haemorrhage after CEA is post-operative hypertension and blood pressure lability.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Tags: Editorial Source Type: research
CONCLUSION: This PSM based observation reconfirmed previous trial results in both asymptomatic and symptomatic patients with carotid artery stenosis in routine clinical practice: CEA showed lower 30 day MACE and mid-term restenosis rates than CAS. PMID: 28893482 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
We report the case of a man with stroke due to tandem internal carotid artery/middle cerebral artery occlusion, who underwent initially ineffective intravenous thrombolysis (IVT) and endovascular treatment. Early anticoagulation with apixaban was started after 48 h of IVT, given a newly diagnosed nonvalvular atrial fibrillation. Spontaneous partial recanalization of the cervical internal carotid artery was noted, and carotid endarterectomy was performed 72 h after IVT and 8 h after the last dose of apixaban. Surgery was conducted without any complication and the patient was discharged 7 days after onset with a residu...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: Case Reports Source Type: research
Conclusions—Overall, selection of sites with high enrollment rates will likely require customization to align the sites selected to the factor under study in the trial.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02089217.
Source: Stroke - Category: Neurology Authors: Tags: Stent, Cognitive Impairment, Ischemic Stroke Original Contributions Source Type: research
ConclusionsIn a major Danish stroke centre, the national recommended time limit of 4 days in patients with stroke or transient ischaemic attack for screening for carotid stenosis was met in almost all patients. No patients were excluded from surgery as a result of a time limit of 14 days from admission to surgery being exceeded. Of all patients screened, 1·2% underwent carotid endarterectomy.
Source: Clinical Physiology and Functional Imaging - Category: Radiology Authors: Tags: Original Article Source Type: research
After an acute ischemic stroke, clinicians pursue further diagnostic assessment to identify the most plausible causes and tailor secondary prevention strategies. Available treatments with a high level of evidence for reducing recurrence stroke risk might include long-term oral anticoagulation in patients with a major-risk cardioembolic source (atrial fibrillation, prosthetic valves, etc), carotid endarterectomy in minor ischemic stroke related to moderate to severe internal carotid artery atherosclerotic stenosis, and best-practice medical management in those with lacunar stroke due to cerebral small vessel disease.1 Howev...
Source: Neurology - Category: Neurology Authors: Tags: Stroke in young adults, All Clinical trials, All Cerebrovascular disease/Stroke, Embolism, Infarction EDITORIALS Source Type: research
Background— Atherosclerotic plaque rupture is accompanied by an acute decrease in the carotid plaque expression of micro-RNAs (miRs)-221 and miR-222. Circular RNA (circR)-284 is a potential inhibitor of miR-221/miR-222 activity. We aimed to determine whether changes in the serum levels of these noncoding RNAs are observed in patients with asymptomatic high-grade carotid disease versus patients with acutely symptomatic carotid disease and recent ischemic stroke. Additionally, we tested the use of functionally related noncoding RNA pairs to enhance the discriminatory power of noncoding RNAs as circulating biomarkers. ...
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Biomarkers, Functional Genomics, Cardiovascular Surgery, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Articles Source Type: research
Aim: Of all ischemic strokes 15-20% result from carotid occlusive disease.Of these up to 80% occur without previous transient ischemic attack The prevalence of asymptomatic carotid artery stenosis (CAS) in general population is 2-8%.Annual risk of ipsilateral stroke is currently estimated to be 1-2% meaning that routin CAE is not justified.However there are patients with substantial higher risk whom CAE is still indicated in.Hence risk stratification is needed.One of the options is to test intracranial haemodynamic by Transcranial Color-coded Sonography (TCCS) at rest and cerebrovascular reserve (CVR).There is evidence tha...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
CONCLUSION: CEA performed within 48 hours was associated with a higher risk of complications compared with surgery performed 48 hours-14 days after the most recent ischaemic event. PMID: 28755855 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
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