Effects of butylphthalide on cognitive decline in diabetic rats.

Effects of butylphthalide on cognitive decline in diabetic rats. Mol Med Rep. 2017 Oct 03;: Authors: Tian Z, Wang J, Wang Y, Zhang M, Zhou Y Abstract Butylphthalide, a component extracted from seeds of Chinese celery, is an effective neuroprotective agent used for the treatment of ischemic stroke and dementia. Diabetes may cause central nervous system damage, and diabetes is closely associated with dementia. The aim of the present study was to investigate the effects of butylphthalide on cognitive impairment in a streptozotocin‑induced diabetic rat model, and the underlying mechanisms of action. A total of 30 healthy male Sprague Dawley rats were randomly divided into the following 2 groups: Normal control (NC; n=10) and diabetes model (DM) groups (n=20). Diabetes was induced in rats in the DM group by intraperitoneal injection of streptozotocin, and these rats were further subdivided into the following 2 groups: Diabetic control (n=10) and butylphthalide‑treated groups (n=10). Following 8 consecutive weeks of treatment, a Morris water maze test was performed and the levels of blood fasting plasma glucose (FPG), superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β, and IL‑6 inflammatory cytokines in the hippocampus were measured. FPG levels were significantly decreased in the butylphthalide‑treated group when compared with the DM group. In addition, cognitive deficit...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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AbstractPurpose of ReviewSouth Asians (SA) are at a higher risk for stroke and vascular dementia due to the disproportionate burden of diabetes, hypertension, and dyslipidemia. This review summarizes the rationale for screening, early detection, and aggressive control of metabolic factors, and critically examines the published literature on primary and secondary stroke prevention.Recent FindingsSouth Asians have a higher prevalence of diabetes than non-SA. SA with diabetes are at a higher risk of recurrent ischemic stroke and have a higher incidence of stroke-related dementia compared to non-South Asians.SummarySouth Asian...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Chronic obstructive pulmonary disease (COPD) is associated with increased risk of coronary atherosclerosis. However, its impact on the long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) has not been described. Using the National Health Insurance Research Database of Taiwan, we identified 215275 adult patients who underwent first-time PCI between 2000 and 2012. Among them, the outcomes of patients with COPD (n = 24900) and without COPD (n = 190375) were compared. Baseline demographics and 13-year overall mortality and adverse cardiac outcomes after PCI (i.e., ischemic events, repeat revascula...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Publication date: December 2017 Source:Canadian Journal of Cardiology, Volume 33, Issue 12 Author(s): Lena Rivard, Paul Khairy Atrial fibrillation (AF) and dementia are major health issues, with growing evidence suggesting a consistent association between AF and all forms of dementia. Although dementia and AF share several risk factors, the association appears to be independent of a history of clinical stroke and other comorbidities such as hypertension, heart failure, and diabetes. Proposed mechanisms linking AF to cognitive decline include altered hemodynamics resulting in cerebral hypoperfusion, inflammation, genetic f...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract Background/AimsLacunar infarct, a small subcortical ischemic lesion, is a known risk factor for future cognitive impairment, dementia, and stroke. We evaluated the relationship between fatty liver disease(FLD) and lacunar infarct in a healthy general population. MethodsSubjects who underwent brain magnetic resonance imaging(MRI) and abdominal ultrasonography(US) during health check‐ups from 2007‐2009 were included. FLD was diagnosed by US. Subjects with a history of cerebrovascular disease, radiological findings consistent with cerebrovascular stenosis, or cerebral small vessel disease were excluded. ResultsOf...
Source: Liver International - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
This study aimed to investigate the associations of the plasma levels of sRAGE and esRAGE in ischemic stroke (IS) patients with and without dementia. This cross-sectional study recruited patients with IS at a university medical center. Vascular dementia was defined as the scale of Clinical Dementia Ranking (CDR)  ≥ 1. Standard enzyme-linked immunosorbent assay was used to measure the plasma concentration of sRAGE and esRAGE. From November 2014 to October 2015, a total of 172 IS patients (mean age: 72.1 ± 7.5 years, 64.5% male) were recruited, including 73 with CDR = 0, 63 with C...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
Background and Purpose—Type 2 diabetes mellitus (T2DM) is associated with diseases of the brain, kidney, and vasculature. However, the relationship between T2DM, chronic kidney disease, brain alterations, and cognitive function after stroke is unknown. We aimed to evaluate the inter-relationship between T2DM, impaired renal function, brain pathology on imaging, and cognitive decline in a longitudinal poststroke cohort.Methods—The TABASCO (Tel Aviv brain acute stroke cohort) is a prospective cohort of stroke/transient ischemic attack survivors. The volume and white matter integrity, ischemic lesions, and brain a...
Source: Stroke - Category: Neurology Authors: Tags: Diabetes, Type 2, Cognitive Impairment, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
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