Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.

Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.
Cell Mol Life Sci. 2017 Oct 07;:
Authors: Lopez-Mejia IC, Castillo-Armengol J, Lagarrigue S, Fajas L
Abstract
In the course of the last decades, metabolism research has demonstrated that adipose tissue is not an inactive tissue. Rather, adipocytes are key actors of whole body energy homeostasis. Numerous novel regulators of adipose tissue differentiation and function have been identified. With the constant increase of obesity and associated disorders, the interest in adipose tissue function alterations in the XXIst century has become of paramount importance. Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies.
PMID: 28988292 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - October 7, 2017 Category: Cytology Authors: Lopez-Mejia IC, Castillo-Armengol J, Lagarrigue S, Fajas L Tags: Cell Mol Life Sci Source Type: research