Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial

Publication date: Available online 10 October 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Sueppong Gowachirapant, Nidhi Jaiswal, Alida Melse-Boonstra, Valeria Galetti, Sara Stinca, Ian Mackenzie, Susan Thomas, Tinku Thomas, Pattanee Winichagoon, Krishnamachari Srinivasan, Michael B Zimmermann Background Iodine deficiency during pregnancy might be associated with reduced intelligence quotient (IQ) score in offspring. We assessed the effect of iodine supplementation in mildly iodine-deficient pregnant women on neurodevelopment of their offspring in areas where schoolchildren were iodine sufficient. Methods In this randomised, placebo-controlled trial, pregnant women in Bangalore, India, and Bangkok, Thailand, were randomly assigned (1:1) to receive 200 μg iodine orally once a day or placebo until delivery. Randomisation was done with a computer-generated sequence and stratified by site. Co-primary outcomes were verbal and performance IQ scores on the Wechsler Preschool and Primary Scale of Intelligence Third Edition (WPPSI-III) and the global executive composite score from the Behaviour Rating Inventory of Executive Function-Preschool Version (BRIEF-P) in the children at age 5–6 years. The trial was double-blinded; some unmasking took place at age 2 years for an interim analysis, but participants and nearly all investigators remained masked to group assignment until age 5–6 years. Analysis was by intention to treat using mixed-effects m...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research