PodMed – Week of September 11, 2017
This week’s topics include a new antibody for asthma, early treatment in COPD, mumps vaccine to curtail an outbreak, and medical exemptions from routine vaccinations. Program notes: 0:38 Avoiding vaccines with medical exemptions 1:38 More people who are vaccinated the less likely an outbreak 2:36 Total went down but others are gaming the system 3:23 […]
ConclusionsBronchodilator dose responsiveness may be useful for phenotyping and may be of utility in practice and future studies focused on asthma outcomes or quantification of treatment responses. In children and adolescents, this phenotype of poor bronchodilator responsiveness may be associated with periods of relatively stable disease yet marked airway constriction in response to triggers, including tobacco smoke, respiratory infections/pneumonia, and aeroallergens.
Publication date: Available online 9 October 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Sande O. Okelo, Andrew L. Bilderback, Maria Fagnano, Jill S. Halterman
ConclusionsCommunity pharmacist–delivered inhaler training informed by a digital technology improved adherence and health status.
ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).
ConclusionsPatients may adapt their ICS use to their current needs without this impacting later RDAC.
Publication date: Available online 12 October 2019Source: Veterinary MicrobiologyAuthor(s): Haiyan Sun, Jung-Hyang Sur, Sarah Sillman, David Steffen, Hiep L.X. VuAbstractThe substantial genetic diversity exhibited by influenza A viruses of swine (IAV-S) represents the main challenge for the development of a broadly protective vaccine against this important pathogen. The consensus vaccine immunogen has proven an effective vaccinology approach to overcome the extraordinary genetic diversity of RNA viruses. In this project, we sought to determine if a consensus IAV-S hemagglutinin (HA) immunogen would elicit broad protective ...
[New Times] Rwanda is planning a big vaccination campaign against the Ebola Virus Disease (EBV) for adults, adolescents, and children aged two years living within the vicinity of a possible Ebola outbreak.
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Qiqi Xin, Rong Yuan, Weili Shi, Zhengchuan Zhu, Yan Wang, Weihong CongAbstractInflammatory disorders result from abnormal immune response and their incidence has increased recently. Thus, there is an urgent need to discover new treatments for inflammatory disorders. In recent years, the natural products contained in Chinese herbs have attracted much attention worldwide owing to their anti-inflammatory effects. Paeoniflorin (PF) is a bioactive compound purified from the Chinese herb Paeonia lactiflora and reports have recently emerged suggesti...
In this study, we generated two recombinant IHNV strains rIHNV-M(PH>A4) and rIHNV-G(PS>A4) with mutations in the L domains (PPPH to AAAA or PSAP to AARA) of IHNV by reverse genetics and explored the effect of the mutations on budding and pathogenicity of the two recombinant viruses. The RT-qPCR results showed that the production levels of the extracellular particles of rIHNV-M(PH>A4) or rIHNV-G(PS>A4) declined significantly, compared with those of wild-type (wt) IHNV HLJ-09. Furthermore, the challenge test showed that the survival rates of juvenile rainbow trout challenged with rIHNV-M(PH>A4) or rIHNV-G(PS&g...
(MedPage Today) -- This week's topics include a new antibody for asthma, early treatment in COPD, mumps vaccine to curtail an outbreak, and medical exemptions from routine vaccinations