Compton camera study for high efficiency SPECT and benchmark with Anger system.
In this study we compare a commercial SPECT-Anger device, the General Electrics Healthcare Innia system with a High Energy General Purpose (HEGP) collimator, and the Compton camera prototype under development by the French collaboration CLaRyS, through Monte Carlo simulations (GATE - GEANT4 Application for Tomographic Emission - version 7.1 and GEANT4 version 9.6, respectively). Given the possible introduction of new radio-emitters at higher energies intrinsically allowed by the Compton camera detection principle, the two detectors are exposed to point- like sources at increasing primary gamma energies, from actual isotopes already suggested for nuclear medicine applications. The Compton camera prototype is rst characterized for SPECT application by studying the main parameters aecting its imaging performance: detector energy resolution and random coincidence rate. The two detector performances are then compared in terms of radial event distribution, detection eciency and nal image, obtained by gamma transmission analysis for the Anger system, and with an iterative List Mode-Maximum Likelihood Expectation Maximization (LM-MLEM) algorithm for the Compton reconstruction. The results show for the Compton camera a detection eciency increased by a factor larger than an order of magnitude with respect to the Anger camera, associated with&am...
Source: Physics in Medicine and Biology - Category: Physics Authors: Fontana M, Dauvergne D, Letang JM, Ley JL, Testa E Tags: Phys Med Biol Source Type: research