An update on the genetics of pre-eclampsia.

An update on the genetics of pre-eclampsia. Minerva Ginecol. 2017 Oct 09;: Authors: Agius A, Sultana R, Camenzuli C, Calleja-Agius J, Balzan R Abstract Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of preeclampsia include immune maladaptation, haemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic factors that might be responsible for the pathogenic changes taking place. Pre-eclampsia has been referred to as a primipaternity disease. A number of studies examined the contribution of paternal genes in pre-eclampsia. Although there is evidence that paternal genes significantly increase the risk of pre-eclampsia, there is still inconclusive evidence whether having the same partner is a protective factor. Gene expression, through imprinting and epistasis, also play an important role in the pathogenesis of this disorder. Pre-eclampsia remains a disease of theories. Despite the growing body of research exploring this complex disorder, the aetiology of pre-eclampsia remains elusive and the struggle is still ongoing to find an effective predictive test that can d...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research