Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.

CONCLUSIONS: These results indicate that cellular factors regulating mechanisms of protein carbonylation may be different depending on pathological diagnosis of NASH. Furthermore these studies are the first to use LC-MS/MS analysis of carbonylated proteins in human NAFLD and explore possible mechanistic links with end stage cirrhosis due to fatty liver disease and the generation of reactive aldehydes. PMID: 28988798 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28988798?dopt=Abstract

Source: Free Radical Biology and Medicine - October 5, 2017 Category: Biology Authors: Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR Tags: Free Radic Biol Med Source Type: research