Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III

Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III Emerging Microbes &Infections 6, e89 (October 2017). doi:10.1038/emi.2017.79 Authors: Yanling Wu, Shun Li, Lanying Du, Chunyu Wang, Peng Zou, Binbin Hong, Mengjiao Yuan, Xiaonan Ren, Wanbo Tai, Yu Kong, Chen Zhou, Lu Lu, Xiaohui Zhou, Shibo Jiang &Tianlei Ying
Source: Emerging Microbes and Infections - Category: Infectious Diseases Authors: Tags: cryptic epitope human monoclonal antibodies Zika virus Source Type: research

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This report describes that birth defects potentially related to Zika virus infection during pregnancy increased fourfold in Puerto Rico and the U.S. Virgin Islands, areas with widespread local transmission of Zika virus during the study period.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Birth Defects MMWR Morbidity & Mortality Weekly Report Zika Virus Source Type: news
West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. For the efficient production of these antibodies, B cells interact directly with CD4 helper T cells that recognize peptides from E or the two other structural proteins (capsid-C and membrane-prM/M) of the virus. However, the specific protein sites yielding such helper epitopes remain unknown. Here, we explored ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
An immune-boosting skin cream applied directly to mosquito bites stopped viral infections in mice. If approved for human use, it could help prevent mosquito-borne viruses like Zika
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Yes. However, very probably not because of the novel coronavirus that has appeared in China. This seems to be front page headlines in every media outlet on the planet, and  the World Health Organization has convened a meeting to decide whether to declare an official Global Health Emergency.This sort of flapdoodle happens every time a novel pathogen appears. Back when I lived in the Hub of the Universe a mosquito-borne disease called West Nile virus appeared (having formerly been large confined to, yes, west of the Nile). For weeks, every time a new case was identified it would be on the front page of the Boston Globe....
Source: Stayin' Alive - Category: American Health Source Type: blogs
Authors: Maucourant C, Queiroz GAN, Samri A, Grassi MFR, Yssel H, Vieillard V Abstract Zika virus (ZIKV) is an emerging arbovirus that causes a mosquito-borne disease. Although infection with ZIKV generally leads to mild disease, its recent emergence in the Americas has been associated with an increase in the development of the Guillain-Barré syndrome in adults, as well as with neurological complications, in particular congenital microcephaly, in new-borns. Over the five past years, through the combined efforts of the scientific community, comprehensive remarkable progress aimed at deciphering the clinical, ...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
(Wiley) Emerging viral infections -- from bird flu to Ebola to Zika infections -- pose major threats to global public health, and understanding their origins can help investigators design defensive strategies against future outbreaks. A new study published in the Journal of Medical Virology provides important insights on the potential origins of the most recent outbreak of viral pneumonia in China, which started in the middle of December and now is spreading to Hong Kong, Singapore, Thailand, and Japan.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(University of Leeds) A skin cream used to treat warts and skin cancer could help protect people against viral diseases such as Zika and dengue, according to new research from the University of Leeds.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Zika virus (ZIKV), a flavivirus, has recently emerged as a significant pathogen.1 In 2016, the World Health Organization recognized it as a global health emergency due to its spread throughout the Americas and its links to an increase in the number of neonates with congenital microcephaly.2 Subsequently, ZIKV was identified as the causative pathogen of congenital ZIKV infection in which severe neurological impairment and brain abnormalities may occur.3 It has been estimated that, among pregnant women with known maternal ZIKV infection during pregnancy, approximately a quarter of foetuses will become congenitally infected, ...
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
AbstractGuillain –Barré syndrome (GBS) is an acute-onset, immune-mediated polyradiculoneuropathy, often precipitated by an antecedent infection. An association of GBS with vector-borne viral infections has been suggested, with evidence for the involvement of Zika, Dengue, Chikungunya and West Nile virus (WNV). Th is prospective case–control study was conducted to identify vector-borne viral infections in GBS. Thirteen individuals newly diagnosed as GBS were enrolled. Disease severity, prognostic factors and nerve conduction patterns were assessed. Eleven individuals with non-infectious conditions requiri...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Zika virus (ZIKV) is an emerging arthropod-borne virus and belongs to the Flaviviridae family. The infection of ZIKV has become the global health crisis because of its rapid spread and association with severe neurological disorders, including congenital microcephaly and Guillain-Barre Syndrome. To identify host factors contributing to ZIKV pathogenesis, transcriptomic landscape in ZIKV-infected cells was examined with mRNA microarray analysis and we observed that the expression of hydroxycarboxylic acid receptor 2 (HCAR2) could be significantly induced by ZIKV infection. By utilizing two IRE1 inhibitors and XBP1-specific s...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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