MCL-1 Up-Regulation through MAPK Activation Confers Acquired Resistance to BCL-2 Inhibitor ABT-199 in Pre-Clinical AML Models

In this study we investigated mechanisms of acquired resistance to venetoclax in preclinical AML models.

Source: Clinical Lymphoma, Myeloma and Leukemia - October 1, 2017 Category: Hematology Authors: Qi Zhang, Lina Han, Rongqing Pan, Ce Shi, Ryan Jeremy, Man Chun John Ma, Steven Kurtz, Hong Mu, Vivian R. Ruvolo, Helen Ma, Yingchang Mi, Jeffrey Tyner, Letai Anthony, Richard Eric Davis, Michael Andreeff, Marina Konopleva Tags: Acute Myeloid Leukemia Source Type: research