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Impact of type 2 diabetes mellitus on in-hospital-mortality after major cardiovascular events in Spain (2002 –2014)

Diabetes mellitus has long been associated with cardiovascular events. Nevertheless, the higher burden of traditional cardiovascular risk factors reported in high-income countries is offset by a more widesprea...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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Sodium glucose co‐transporter 2 (SGLT2) inhibitors and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are antihyperglycaemic agents with weight‐lowering effects. The efficacy and safety of the SGLT2 inhibitor canagliflozin as add‐on therapy in Japanese patients with type 2 diabetes mellitus (T2DM) and inadequate glycaemic control with a GLP‐1RA (≥12 weeks) were evaluated in this phase IV study. Patients received canagliflozin 100 mg once daily for 52 weeks. Efficacy endpoints included the change in glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), bodyweight, systolic blood pressure (SBP), ...
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: BRIEF REPORT Source Type: research
Authors: Zhang X, Chee WK, Liu S, Tavintharan S, Sum CF, Lim SC, Kumari N Abstract Purpose: Osteopontin (OPN) is a proinflammatory cytokine with diverse functions. Increased levels of OPN in vitreous fluid have been reported in patients with diabetic retinopathy (DR); however, studies on circulating OPN levels in DR are limited. We aim to examine the association of plasma OPN levels with the presence and severity of DR in a multiethnic cohort with type 2 diabetes mellitus (type 2 diabetes) in Singapore. Methods: Plasma levels of OPN were measured using enzyme-linked immunosorbent assay. Digital color fundus pho...
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
This article summarizes the milestones in the development of ertugliflozin leading to its first approval for T2DM.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionAfter induction IIT, metformin was superior to intermittent IIT for maintaining β‐cell function and glycaemic control over 2 years. The strategy of induction and maintenance therapy to preserve β‐cell function warrants exploration in early T2DM.
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This article is protected by copyright. All rights reserved.
Source: Hippocampus - Category: Neurology Authors: Tags: Research Article Source Type: research
ConclusionAmong Chinese T2DM insulin-na ïve patients, those who initiated premixed insulin had a lower per-day antidiabetic medication cost than those who initiated long-acting insulin.FundingLilly Suzhou Pharmaceutical Co. Ltd, China.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
Conclusions and RelevanceOur findings highlight the importance of good glycaemic control as a modifiable risk factor for both dry eye symptoms and tear film instability in patients with T2DM.
Source: Clinical and Experimental Ophthalmology - Category: Opthalmology Authors: Tags: Original Article Source Type: research
ConclusionsOur systematic review and meta-analysis indicates that cigarette smoking might be a potential factor for the development of albuminuria in adults with T2DM. Future studies are required to investigate the association between smoking cessation and intensity and incident albuminuria in adults with T2DM.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Hennessy S, Cocoman AM Abstract Individuals with a severe mental illness have a gap in life expectancy of up to twenty years in comparison to the general population. Nurses who work in mental health services have been identified as best placed to improve the physical health outcomes of individuals with mental illness. The literature identifies a lack of nursing knowledge related to physical health care and the presence of metabolic syndrome which is impeding nurses in providing essential physical health care to patients. An integrated literature review was carried out due to the dearth of research evidence...
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
Authors: Wang JM, Ye SD, Li SM, Hu W Abstract OBJECTIVE: To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] and the lipid profile, inflammatory cytokines, and endothelial function in diabetic patients. PATIENTS AND METHODS: A total of 77 patients with type 2 diabetes mellitus treated in our hospital from January 2015 to March 2017 and 73 healthy volunteers were selected. The 25(OH)D, lipids, inflammatory factors, and endothelial function were compared between the two groups. The levels of 25(OH)D in diabetic patients were also compared to detect the levels of serum lipids and inflammatory cyto...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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