A randomized, Phase IIb study investigating oliceridine (TRV130), a novel & micro;-receptor G-protein pathway selective ( & micro;-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty

Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

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Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: The use of liposomal bupivacaine may contribute to a reduction in length of stay, hospital costs, and 30-day readmission rates for abdominal and breast reconstructive procedures, which could contribute to a favorable economic profile from a system view. Focusing on the measurement and improvement of value in the context of whole, definable, patient processes will be important as we transition to value-based payments.
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Plastic Surgery Focus: Special Topics Source Type: research
Conclusions: Overall, plastic surgeons seem to be in compliance with proposed American College of Surgeon’s opioid prescription guidelines. However, there remains a lack of evidence regarding appropriate opioid prescribing patterns for plastic surgeons.
Source: Plastic and Reconstructive Surgery Global Open - Category: Cosmetic Surgery Tags: Special Topic Source Type: research
Condition:   Pain Management Interventions:   Drug: Tramadol;   Drug: Morphine;   Other: Placebo Sponsor:   Avenue Therapeutics, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Body contouring procedure is a catchall that includes mastopexy, abdominoplasty, liposuction, and lower body lift. It is well known that optimal postoperative pain control decreases hospitalization length of stay and promotes early ambulation, which in turn decreases the incidence of complications. There have been many innovations in pain control beyond opiate medications, including prolonged administration of local anesthesia, regional blocks, and the use of a multimodal regimen which utilizes nonopiates. All approaches aim to decrease oral or intravenous opiate use and, therefore, encourage faster return to normal bowel ...
Source: Clinics in Plastic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
Learning Objectives: After reading this article, the participant should be able to: 1. Differentiate between techniques for standard abdominoplasty and lipoabdominoplasty. 2. Assess patients for risk associated with abdominoplasty alone and combined with other procedures. 3. Implement newer modalities for abdominoplasty perioperative pain management. 4. Better understand the implications and techniques for rectus diastasis correction by rectus sheath plication. 5. Understand the evidence for eliminating the need for drains in abdominoplasty. Summary: This update to past Maintenance of Certification articles offers new...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: MOC-CME Source Type: research
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