Mesenchymal Stromal Cell ‐Derived Extracellular Vesicles Provide Long‐term Survival after Total Body Irradiation without additional Hematopoietic Stem Cell Support

This article is protected by copyright. All rights reserved. Hypothetical mode of action of mMSC versus extracellular vesicles after i.v. injection into lethally irradiated mice. (A) mMSC accumulate in the lung after i.v. injection into lethally irradiated recipients. There, a polarization of tissue resident and immigrating macrophages takes place, changing the pro‐inflammatory environment after irradiation into an anti‐inflammatory one. Although mMSC were trapped in the lung, decreased inflammation, oxidative stress and apoptosis as well as enforced cell cycle in the bone marrow have been detected. (B) Mouse MSC‐derived extracellular vesicles after i.v. injection into lethally irradiated recipients transport several cargos including proteins and various RNAs directly into the bone marrow without notable accumulation in other tissues. EV target bone marrow‐resident HSC and stimulate management of oxidative stress, cell cycle and probably other regenerative processes.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Regenerative Medicine Source Type: research