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New Connected Devices Seek to Tackle Drug Noncompliance

Noncompliance with drug regimens continues to be a significant healthcare concern. “Today, 60% of patients fail to comply with their medication regimen,” Sai Shankar, director business development - connected devices for Aptar Pharma, tells MD+DI.   Aptar Pharma believes that turning metered-dose inhalers (MDIs) and dry-powder inhalers (DPIs) into connected devices could have an impact. “This can improve patient engagement and significantly increase dose adherence and improve patient health outcomes, as patients manage their treatments more effectively,” says Shankar. “Connected devices provide objective monitoring and real-time data with digital solutions. This improves patient adherence, which reduces hospitalization events in chronic diseases. Hospitalization reduction decreases costs to payers, creating value in healthcare system.”   Aptar Pharma is partnering with a digital health solution provider to develop a portfolio of connected devices such as MDIs and DPIs. “Aptar Pharma offers drug-delivery devices that can bring in the full connected functionality and integrate them with software solutions that are accessible to patients/consumers,” he says.   The company will be highlighting several technologies at the upcoming CPhI Worldwide on October 24-26, 2017, at Messe Frankfurt, Germany.   “For respiratory, we will be featuring our c-Devices portfolio at CPhI, which includes ou...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news

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CONCLUSIONS: In this cohort, recent pregnancy was not associated with high-risk pathological features of differentiated thyroid cancer. These findings provide reassurance with regards to the concern that pregnancy may act as a potential stimulus for thyroid cancer growth. PMID: 29160171 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: The results of this meta-analysis indicates that diagnostic radiation exposure is associated with an increased thyroid cancer risk. Therefore, to the extent that it will not compromise the information being sought, radiation exposure to the thyroid should be minimized during diagnostic examinations. PMID: 29160170 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSIONS: The flavonoid rutin seems to be an important stimulator of radioiodide uptake, acting at multiple levels, an effect that can be due to decreased oxidative stress, reduced AMPK activation, or both. Since thyroid iodide uptake is crucial for effective radioiodine therapy, our results suggest that rutin could be useful as candidate for adjuvant in radioiodine therapy. PMID: 29160164 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Authors: Valderrabano P, Khazai L, Thompson ZJ, Sharpe SC, Tarasova VD, Otto KJ, Hallanger-Johnson JE, Wadsworth JT, Wenig BM, Chung CH, Centeno BA, McIver B Abstract BACKGROUND: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. We assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly ...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Abstract Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this l...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
Authors: Pingwara R, Witt-Jurkowska K, Ulewicz K, Mucha J, Tonecka K, Pilch Z, Taciak B, Zabielska-Koczywas K, Mori M, Berardozzi S, Botta B, Rygiel TP, Krol M Abstract Myeloid-derived suppressor cells (MDSCs) support tumor development by stimulation of angiogenesis and immune response inhibition. In our previous study, we showed that interferon lambda 2 (IFN-λ2), secreted by MDSCs, enhances production of pro-angiogenic factors by cancer cells via phosphorylation of STAT3 and therefore promotes blood vessels formation. In the present study IFN-λ2 level was evaluated by ELISA in serum of tumor-bearing ...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
This study showed, for the first time, the mechanism of HCAR1-mediated chemoresistance to doxorubicin through regulation of ABCB1 transporter. We observed the HCAR1 agonists L-lactate, D-lactate and 3,5-dihydroxybenzoic acid (DHBA) induced up-regulation of ABCB1. HCAR1 silencing decreased ABCB1 mRNA and protein by 80% and 40%, respectively. Moreover, cellular doxorubicin accumulation decreased by 30% after DHBA treatment, while HCAR1 silencing increased accumulation of ABCB1 substrates by nearly 2-fold. Based on growth inhibition assays, cell cycle analysis, and annexin V staining assays, we demonstrated that HCAR1 enhance...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Dalton Trans., 2017, Advance Article DOI: 10.1039/C7DT03385K, PaperLorenzo Biancalana, Stefano Zacchini, Nicola Ferri, Maria Giovanna Lupo, Guido Pampaloni, Fabio Marchetti The cytotoxic activities of novel Ru(II) arene complexes with variably mono-substituted phosphine ligands have been assessed towards MDA-MB-231 and A2780 cancer cell lines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2017, Advance Article DOI: 10.1039/C7CC07664A, CommunicationMeng Li Liu, Hong Yan Zou, Chun Mei Li, Rong Sheng Li, Cheng Zhi Huang Selenium nanoparticles with good water solubility and excellent biocompatibility are used for the first time as a light-scattering nanoprobe with aptamer modification to image nucleolin-overexpressing cancer cells through dark-field microscopy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Conclusion: Multiple components of the metabolic syndrome independently affected the risk for severe liver disease. Alcohol was significant even when average alcohol consumption was within the limits currently defining non‐alcoholic fatty liver disease. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
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