Giving antibiotics prior to low-risk surgery may prevent resistance
Researchers report that surgical patients given antibiotics prior to some operations are not at increased risk for antibiotic-resistant infections after surgery.
Authors: Cho JC, Childs-Kean LM, Zmarlicka MT, Crotty MP Abstract Omadacycline is a novel aminomethylcycline antimicrobial agent that is available in both oral and intravenous formulations. The distinguishing structural characteristics of omadacycline from other tetracyclines allow for its continued antimicrobial activity in the presence of traditional tetracycline resistance mechanisms (efflux pumps and ribosomal protection proteins). Omadacycline has been found to have potent activity against antibiotic-resistant pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, e...
Conclusions The results of this study found that patient severity and onset delays were positively associated with both MRSA and burden and that the effect of methicillin resistance remained significant after adjustment.
Up to 1.8% of all hospitalizations are for an acute bacterial skin and skin structure infections (ABSSSI) . Often these serious skin infections require intravenous antibiotics, hospitalization, and/or surgical intervention [2,3]. The majority of ABSSSI are caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible S. aureus (MSSA), and beta-hemolytic streptococci [3,4]. Although many antibiotics are available to treat ABSSSI, only a few are available for ABSSSI caused by multidrug resistant (MDR) bacteria, and some of these are limited by safety, tolerability...
We tested the in vitro activity of oritavancin against 185 staphylococci associated with prosthetic joint infection (PJI), including 37 methicillin-resistant S. aureus (MRSA), 67 methicillin-susceptible S. aureus (MSSA), 59 methicillin-resistant S. epidermidis (MRSE) and 22 methicillin-susceptible S. epidermidis (MSSE) isolates. The oritavancin MIC50 for S. aureus and MSSE was 0.03 μg/mL, and for MRSE was 0.06μg/mL; MIC90 for S. aureus and S. epidermidis was 0.12μg/mL for both the methicillin-resistant and -susceptible subgroups.
In conclusion, the developed ZnO/Ag surfaces exhibit not only high antibacterial activity but also some antifungal activity. Graphical abstract
CONCLUSIONS: Dalbavancin proved to be active against MRSA and MRSE biofilms. The combination of dalbavancin with heparin is a promising catheter lock solution that has the advantage of locking the catheter at home for 7 days. PMID: 29771236 [PubMed - as supplied by publisher]
Svensson Stadler L Abstract Two strains included in a whole-genome sequencing project for methicillin-resistant Staphylococcus aureus (MRSA) were identified as non-Staphylococcus aureus when the sequences were analysed using the bioinformatics software ALEX (www.1928diagnostics.com, Gothenburg, Sweden). Sequencing of the sodA gene of these strains identified them as Staphylococcus argenteus. The collection of MRSA in western Sweden was checked for additional strains of this species. A total of 18 strains of S. argenteus isolated between 2011 and December 2017 were identified. PMID: 29771232 [PubMed - as supplied by publisher]
We present a clinical case of a cystic fibrosis (CF) patient, with multi-drug resistant (MDR) Achromobacter xylosoxidans chronic lung infection who was successfully managed with bacteriophage therapy.
Abstract Clostridium difficile infection (CDI) symptoms range from diarrhea to severe toxic megacolon and even death. Due to its rapid acquisition of resistance, C. difficile is listed as an urgent antibiotic-resistant threat, and has surpassed methicillin-resistant Staphylococcus aureus (MRSA) as the most common hospital-acquired infections in the USA. To combat the pathogen, the new structural class of pseudo peptides that exhibit antimicrobial activities could play an important role. Herein, we report that bis-cyclic guanidine compounds that exhibit potent antibacterial activity against C. difficile with decent...
Conclusion Teicoplanin resistance could occur due to the point mutation in teicoplanin resistant tcaR-tcaA-tcaB operon. Further, studies are warranted for the contribution of point mutation in tcaRAB for reduced teicoplanin susceptibility.