Ovarian reserve tests fail to predict fertility, NIH-funded study suggests

(NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development) Tests that estimate ovarian reserve, or the number of a woman's remaining eggs, before menopause, do not appear to predict short-term chances of conception, according to a National Institutes of Health-funded study of women with no history of infertility. The study appears in the Journal of the American Medical Association.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusion Moderate-to-severe endometriosis was more common in women with East or South East Asian ethnicity in our tertiary referral center. This could be explained by East/South East Asians with minimal-mild disease being less likely to seek care, or genetic/environmental differences that increase the risk of more severe disease amongst East/South East Asians.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
This study examined how fertility factors relate to QOL among YAFCS who received gonadotoxic therapy.MethodA national sample of YAFCS completed an online, anonymous survey. The survey included investigator-designed questions about perceived fertility information needs (five items; Cronbach ’sα = .83) and general QOL (four items;α = .89), the Reproductive Concerns after Cancer Scale (RCACS) and Decisional Conflict Scale (DCS). Analyses included Pearson’s correlation,t tests, and stepwise regression.ResultsParticipants (N = 314) were an average of 30 year...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Uterine fibroids are extremely common smooth muscle tumors found in women of reproductive age. Over 75% of women will develop fibroids prior to menopause. A continued challenge is determining when fibroids are problematic and involved in the etiology of infertility, rather than an incidental finding. Fibroids are classified based on their size and location within the uterus (1). Fibroids that are intracavitary (i.e., entirely within the uterine lumen) or that project into the cavity and significantly distort its shape have been clearly associated with infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
CONCLUSION: Our results show that Epstein-Barr infection is possibly associated with autoimmune ovarian failure. The devastating impact on fertility in such disorder can be successfully avoided by in vitro maturation of oocytes from excised ovarian tissue. PMID: 29618356 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
AbstractSTUDY QUESTIONAre anti-M üllerian hormone (AMH) levels assessed in women aged 32–44 associated with risk of incident early natural menopause?SUMMARY ANSWERWe observed strong, significant associations between lower AMH levels and higher risk of early menopause.WHAT IS KNOWN ALREADYThe ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention. Though AMH is an established marker of menopause timing in older reproductive-aged women, whether AMH is associated with risk of early menopa...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Publication date: Available online 30 March 2018 Source:Case Reports in Women's Health Author(s): Ashima Arora, Shameema Anvar Sadath Genital tuberculosis is usually diagnosed in young women being assessed for infertility. After menopause it usually presents with symptoms resembling endometrial malignancy, such as postmenopausal bleeding, persistent vaginal discharge and pyometra. The diagnosis is made by detection of acid-fast bacilli on microscopy or bacteriological culture and/or presence of epithelioid granuloma on biopsy. Anti-tubercular therapy involves the use of rifampicin, isoniazid, pyrazinamide and ethambutol. ...
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
ConclusionsThese findings suggest that a single dose of 5-FU is mildly ovotoxic, but any effects on ovarian function are likely transient because the primordial follicle population is not depleted. Collectively, these data support the notion that 5-FU is unlikely to impact on the long-term fertility of women.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Abstract It has been more than 15 years since the measurement of serum anti‐Müllerian hormone (AMH) first allowed the quantitative assessment of ovarian reserve. Meanwhile, the clinical implication of serum AMH has been expanding. The measurement of serum AMH has been applied in various clinical fields, including assisted reproduction, menopause, reproductive disorders and assessment of ovarian damage/toxicity. Well‐known findings about the usefulness of serum AMH revealed by numerous studies executed in the early era include decline with aging, a good correlation with oocyte yield in assisted reproduction, upregu...
Source: Journal of Obstetrics and Gynaecology Research - Category: OBGYN Authors: Tags: Invited Manuscript Source Type: research
Discussion regarding family planning is imperative in women with IBD with a strong recommendation to consider long-acting highly effective contraceptives such as intrauterine devices or implants. Cervical cancer screening should be tailored in women on immunosuppressive medications and all women under 26  years of age should be advised to receive the human papilloma virus vaccination.SummaryAs gastroenterologists will have longitudinal relationships with their female IBD patients, they must be knowledgeable about sex-specific issues during each stage of life from puberty to after menopause to optimize their patient ’s care.
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
Abstract Gonadotropins belong to the family of dimeric glycoprotein hormones and regulate gonadal physiology mediated by G protein-coupled, seven-transmembrane receptors. These glycoprotein hormones are widely used in the clinic to promote ovarian follicle development and for treating some cases of male infertility. We traced the co-evolution of dimeric gonadotropin hormones and their receptors, together with thyrotropin and its receptor. We updated recent findings on human genetic variants of these genes and their association with dizygotic twining, polycystic ovarian syndrome, primary ovarian insufficiency, male...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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