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Structure of aureobasidin A

Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106.Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine, L-proline, allo-L-isoleucine, N-methyl-L-phenylalanine, L-leucine, and L-phenyl-alanine.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Cheng Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment. For potency improvement of cell wall-disrupting agents (CAS, octyl gallate (OG)), antifungal efficacy of thirty-three cinnamic acid derivatives was investigated against Saccharomyces cerevisiae slt2Δ, bck1Δ, mutants of the mitogen-activated protein kinase (MAPK), and MAPK kinase kinase, respectively, in cell wall integrity system, and glr1Δ, mutant of CAS-responsive glutathio...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
In this study, we investigated the effect of ion beam irradiation on A. luchuensis RIB2601 and obtained a high starch-degrading mutant strain U1. Strain U1 showed reduced growth rate, whereas it showed higher α-amylase, glucoamylase, and α-glucosidase activities on a mycelial mass basis than the wild type (wt) strain both on agar plates and in rice koji. In addition, strain U1 showed higher N-acetylglucosamine content in the cell wall and higher sensitivity to calcofluor white, suggesting a deficiency in cell wall composition. Interestingly, produced protein showed higher expression of acid-labile α-amyla...
Source: Journal of General and Applied Microbiology - Category: Microbiology Tags: J Gen Appl Microbiol Source Type: research
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Background: The echinocandins are an important class of antifungal agents, but are administered oncedaily by intravenous (IV) infusion. An echinocandin that could be administered once weekly couldfacilitate earlier hospital discharges and could expand usage to indications where daily infusions areimpractical. Biafungin is a highly stable echinocandin for once-weekly IV administration. The compoundwas found to have a spectrum of activity and potency comparable to other echinocandins. In
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Background: The echinocandins are an important class of antifungal agents, but areadministered once daily by intravenous (IV) infusion. An echinocandin that offers a convenientand more economic dosing schedule is desired.Biafungin is a highly stable echinocandin for intermittent IV administration. The compound wasfound to have a long half-life (T1/2), which may greatly reduce costs even as an IV therapythrough less frequent dosing, allowing earlier discharges for patients with negative fungal
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
: http://bciq.biocentury.com/products/biafungin
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Novelmacrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agentsagainstwild-type and fluconazoleresistantCandidaspecies.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
From Scynexis website (as of 20/10/2017):
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3)-glucan. We evaluated the invitro activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the FKS gene(s) of Candida spp. and Aspergillus spp.MK-3118 demonstrated enhanced efficacy for most C. albicans and C.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
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