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Generation of Broad-Spectrum Antifungal Drug Candidates from the Natural Product Compound Aureobasidin A

This report describes novel chemistry for the modification of AbA.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.7b04140
Source: Journal of Agricultural and Food Chemistry - Category: Food Science Authors: Source Type: research
Young Kim, In-Beom Heo, Jae-Hyuk Yu, Kwang-Soo Shin
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, A. ibericus was found to be a good alternative FOS producer.
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Cheng Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment. For potency improvement of cell wall-disrupting agents (CAS, octyl gallate (OG)), antifungal efficacy of thirty-three cinnamic acid derivatives was investigated against Saccharomyces cerevisiae slt2Δ, bck1Δ, mutants of the mitogen-activated protein kinase (MAPK), and MAPK kinase kinase, respectively, in cell wall integrity system, and glr1Δ, mutant of CAS-responsive glutathio...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
In this study, we investigated the effect of ion beam irradiation on A. luchuensis RIB2601 and obtained a high starch-degrading mutant strain U1. Strain U1 showed reduced growth rate, whereas it showed higher α-amylase, glucoamylase, and α-glucosidase activities on a mycelial mass basis than the wild type (wt) strain both on agar plates and in rice koji. In addition, strain U1 showed higher N-acetylglucosamine content in the cell wall and higher sensitivity to calcofluor white, suggesting a deficiency in cell wall composition. Interestingly, produced protein showed higher expression of acid-labile α-amyla...
Source: Journal of General and Applied Microbiology - Category: Microbiology Tags: J Gen Appl Microbiol Source Type: research
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Background: The echinocandins are an important class of antifungal agents, but are administered oncedaily by intravenous (IV) infusion. An echinocandin that could be administered once weekly couldfacilitate earlier hospital discharges and could expand usage to indications where daily infusions areimpractical. Biafungin is a highly stable echinocandin for once-weekly IV administration. The compoundwas found to have a spectrum of activity and potency comparable to other echinocandins. In
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Background: The echinocandins are an important class of antifungal agents, but areadministered once daily by intravenous (IV) infusion. An echinocandin that offers a convenientand more economic dosing schedule is desired.Biafungin is a highly stable echinocandin for intermittent IV administration. The compound wasfound to have a long half-life (T1/2), which may greatly reduce costs even as an IV therapythrough less frequent dosing, allowing earlier discharges for patients with negative fungal
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
: http://bciq.biocentury.com/products/biafungin
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Novelmacrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agentsagainstwild-type and fluconazoleresistantCandidaspecies.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
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