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Generation of Broad-Spectrum Antifungal Drug Candidates from the Natural Product Compound Aureobasidin A

This report describes novel chemistry for the modification of AbA.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Publication date: May 2018 Source:Journal of Food Composition and Analysis, Volume 68 Author(s): F. Saladino, E. Posarelli, C. Luz, F.B. Luciano, M.T. Rodriguez-Estrada, J. Mañes, G. Meca Aflatoxins (AFs) are produced mainly by the molds Aspergillus flavus and Aspergillus parasiticus. Aflatoxin B1 (AFB1) is classified as carcinogenic to humans. The aim of this study was to evaluate the capacity of different strains of Lactobacilli (Lb.) and Bifidobacteria (Bf.) to reduce the bioaccessibility of AFB1 and aflatoxin B2 (AFB2), spiked in loaf bread, using a dynamic in vitro simulated gastrointestinal digestion system. ...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
Infection of the skin by Aspergillus speciesmost commonly occurs through direct innoculation of damaged skin, in which case it is called primary cutaneous aspergillosis (PCA). PCA is often a devastating and life-threatening infection that has been described in all age groups. Premature neonates are at particular risk due to a smaller pool of monocytes and neutrophils, impaired T-cell activation and an immature skin barrier as well as considerably decreased cord blood TNF- α and IL-6. Skin maceration, moisture buildup and disruption of barrier integrity are believed to contribute to the pathophysiology of PCA, and occ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
Updated Date: Apr 18, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.8b00790
Source: Journal of Agricultural and Food Chemistry - Category: Food Science Authors: Source Type: research
AbstractChronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12  years (2006–2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study. Age of the patients ranged from 12 to 75 year...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
Conclusion: Exposure of organic dust is associated with compromised pulmonary functions and there is a need of formulation of safety guidelines.
Source: Indian Journal of Occupational and Environmental Medicine - Category: Occupational Health Authors: Source Type: research
Abstract The essential oil obtained from Wedelia urticifolia growing in Hunan Province, China, was analyzed for the first time by capillary GC and GC-MS. A total of 67 constituents, representing 98.68% in essential oil were identified. The major constituents of the oil were: α-pinene (8.85%), limonene (6.38%), carvacrol (6.15%), caryophyllene (6.08%), spathulenol (5.49%), sabinene (5.36%), camphor (4.34%). Antimicrobial potential of oil against bacterial strains (Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis, and Staphylococcus aureus), yeast strains (Hansenula anomala and Saccharomy cescere...
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research
Mon, 04/16/2018 - 12:47News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
We assessed the prevalence of potential health hazards to intervention staff and cannabis growers in Belgian indoor cannabis plantations. Surface mold swab samples were taken at 16 Belgian indoor plantations contained mostly Penicillium sp. and Aspergillus...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
Two new isocoumarins, (3R)-methyl-8-hydroxy-6-(hydroxymethyl)-7-methoxydihydroisocoumarin (1) and (3R)-methyl-7,8-dimethoxy-6-(hydroxymethyl)dihydroisocoumarin (2), together with three known isocoumarins (3–5), were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of compounds1 and2 were evaluated. Compounds1 and2 showed anti-TMV activities with inhibition rates of 21.8 and 18.6% at the concentration of 20 μM, respectively.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
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