Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis

ASP9726 is an investigational echinocandin with in vitro activity against Aspergillus species. We evaluated the pharmacokinetics and efficacy of this agent in an established guinea pig model of invasive pulmonary aspergillosis.ASP9726 plasma concentrations were measured in guinea pigs administered either a single dose or multiple doses of this agent at 2.5, 5, and 10 mg/kg of body weight/day by subcutaneous injection. Immunosuppressed guinea pigs were inoculated with A.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news