Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase

AR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these activities has remained unclear. Based on a chemical-genetic profiling approach in yeast, we have found thatAR-12 is an ATP-competitive, time-dependent inhibitor of yeast acetyl coenzyme A synthetase.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Publication date: 5 November 2018 Source:Journal of Molecular Structure, Volume 1171 Author(s): Bharti Mohan, Achintya Jana, Neeladri Das, Sulakshna Bharti, Mukesh Choudhary Three new salen-type copper (II) and nickel (II) complexes viz. [Cu(L)2] (1); [Ni(L)2] (2); [Ni(L1) (DMF)] (3), where HL = 2-((E)-(4-bromo-2-chlorophenylimino) methyl)-6-bromo-4-nitrophenol and HL1= (E)-1-(3,5-dichloro-2-hydroxybenzylidene)-4,4-dimethylthiosemicarbazide; DMF = N, N-dimethylformamide, have been successfully achieved and structurally characterized by single crystal X-ray analysis. The salen-type ligands (HL and HL1) are able to ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Contributors : Yong Kim ; Jae-Hyuk YuSeries Type : Expression profiling by high throughput sequencingOrganism : Aspergillus fumigatusRgsD functioned in asexual development and melanin synthesis. Rax1 involved in the protection against oxidative stresses.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Aspergillus fumigatus Source Type: research
The lifestyle of filamentous fungi depends on the secretion of hydrolytic enzymes into the surrounding medium, which degrade polymeric substances into monomers that are then taken up to sustain metabolism. Thi...
Source: Microbial Cell Factories - Category: Microbiology Authors: Tags: RESEARCH Source Type: research
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Sachin Jain, Philipp Wiemann, Elizabeth Thill, Brett Williams, Nancy P. Keller, Mehdi Kabbage
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: 15 September 2018 Source:Biochemical Engineering Journal, Volume 137 Author(s): Qian Li, Abdullah Al Loman, Nicholas V. Callow, S.M. Mahfuzul Islam, Lu-Kwang Ju Aspergillus foetidus was found to have different optimal pH conditions for producing different carbohydrases including cellulase, xylanase, pectinase, α-galactosidase, polygalacturonase, and invertase. Designs to trigger these conditions sequentially using controlled pH gradients were evaluated for directing the culture through multiple production stages optimal for different enzymes. For production of enzyme mixtures with particularly high...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
Blandino In an open field trial on two agricultural soils in NW Italy, the impact of two seed-applied biostimulants on the rhizosphere bacterial community of young maize plants was evaluated. The 16S rDNA profiling was carried out on control and treated plant rhizosphere samples collected at the 4-leaf stage and on bulk soil. In both soils, the rhizospheres were significantly enriched in Proteobacteria, Actinobacteria, and Bacteriodetes, while the abundances of Acidobacteria, Cloroflexi and Gemmatimonadetes decreased compared with bulk soil. Among the culturable bacteria genera that showed an increase by both biostimu...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, we used the fungus Aspergillus orayzae for the fermentation process. The aqueous extract of fermented Lupin (AEFL) possesses the ability to reduce selenium ion in the presence of gamma rays evidenced by the color changes to red. Elemental composition, surface morphology, size determenation, and identity of selenium nanoparticles (SeNPs) were verified by UV–Vis., TEM, DLS, XRD, EDX, SEM and FT-IR. Antimicrobial activity of SeNPs was tested towards multidrug-resistant (MDR) bacteria, and some pathogenic fungi. TEM with DLS analysis confirmed the formation of sphere isotropic, poly-dispersed SeNPs with av...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
A new study examines the clinical features and treatment outcomes of COPD patients with Aspergillus colonization.BMC Pulmonary Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news
Source: Neurological Sciences - Category: Neurology Source Type: research
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