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Drugs in Clinical Development for Fungal Infections (includes MAT023, encochleated amphotericin B))

Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Abstract BackgroundProspective studies to determine associated risk factors and related outcomes for pulmonary fungal infection (PFI) after pediatric lung transplant (PLT) are lacking. MethodsNIH‐sponsored Clinical Trials in Organ Transplantation in Children enrolled PLT candidates, collecting data prospectively for 2 years post‐transplant. Demographics, signs/symptoms, radiology, pathology and microbiology were collected. Analyses evaluated for PFI‐related risks and outcomes. ResultsIn 59 PLT, pre‐transplant fungal colonization occurred in 6 donors and 15 recipients. Cystic fibrosis (CF) was associated with pre‐...
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
C Agrawal, V Sood, A Kumar, V RaghavanIndian Journal of Nephrology 2017 27(5):392-394 Invasive fungal infections (IFIs) are a significant cause of morbidity in solid organ transplant (SOT) recipients. Common causes among them are Aspergillus, Candida, and Cryptococcus. Antifungal prophylaxis has led to decrease in overall incidence of IFI; however, there is very little decline in the incidence of Cryptococcal infections of SOT recipients because effective prophylaxis is not available against this infectious agent. Spectrum of manifestation of Cryptococcal infection varies in immunocompetent and immunocompromised host with...
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Conclusion The findings of this descriptive cross-sectional study clearly indicate, in wards of the hospital that used wet cooling systems, there was considerable fungal contamination, particularly Aspergillus contamination. These results highlight a clear need for greater attention to the use of non-aqueous or closed circulation cooling systems, especially where susceptible patients receive medical care.
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Summary Environmental conditions for swimming facilities may support fungal growth and also may represent a biological risk for users. However, since previously published studies both cleaning procedures and sanitary regulations are likely to have been improved. The aim of the study was to examine whether attendance to public swimming pools was still a risk factor for fungal infection of the skin in Poland. We investigated the occurrence of mycotic species, in a sample from Polish swimming pools. Detection and identification of isolated species were achieved by cultural and morphological methods. Study revealed high incide...
Source: Mycoses - Category: Research Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study verified whether the water employed in the dental units of two dental clinics at the University of Franca was contaminated with fungi. This study also evaluated the ability of the detected fungi to form biofilms. The high-revving engine contained the largest average amount of fungi, 14.93 ± 18.18 CFU/mL. The main fungal species verified in this equipment belonged to the genera Aspergillus spp., Fusarium spp., Candida spp., and Rhodotorula spp. Among the isolated filamentous fungi, only one fungus of the genus Fusarium spp. did not form biofilms. As for yeasts, all the Candida spp. isolates grew as ...
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
• CD101 is a novel echinocandin with an extended half-life and can be dosed once a week• The activity of CD101 and comparators was evaluated using CLSI broth microdilution methods• A total of 713 invasive fungal isolates collected worldwide during 2015 were evaluated• CD101 activity was comp arable to that of other echinocandins against Candida spp. and Aspergillus spp.• FKS HS-mutant Candida spp. and Cryptococcus spp. displayed elevated CD101 and echinocandin MICs• CD101 will be a valuable addition to treatment options for invasive fungal infections
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research
We present a case of disseminated hepatic, pulmonary, bowel, and appendix mucormycosis successfully treated with antifungal therapy and without surgical intervention. We also review the literature regarding hepatic abscesses and disseminated invasive fungal infections along with current treatment strategies for Mucor infections.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Review Articles Source Type: research
Contributors : Andreas Dix ; Kristin Czakai ; Ines Leonhardt ; Karin Sch äferhoff ; Michael Bonin ; Reinhard Guthke ; Hermann Einsele ; Oliver Kurzai ; Jürgen Löffler ; Jörg LindeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWithin the last decades, invasive fungal infections have gained increasing significance. They are characterized by high mortality rates and are often caused Candida albicans and Aspergillus fumigatus. The increasing number of infections underlines the necessity for additional anti-fungal therapies, which require an extended knowledge of g...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
This study evaluated 2011 –2012 data from 5 hospitals in Saudi Arabia and Lebanon with a combined total of 207,498 discharges. Hospital medical chart data were abstracted for a random sample of patients with each infection type (102 patients – IFI, 93 patients – MRSA pneumonia, and 87 patients—MRSA cSSTI).
Source: Journal of Infection and Public Health - Category: Global & Universal Authors: Source Type: research
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