Patiromer Lowers Serum Potassium When Taken without Food : Comparison to Dosing with Food from an Open-Label, Randomized, Parallel Group Hyperkalemia Study

Background: Patiromer is a sodium-free, nonabsorbed, potassium binder approved for treatment of hyperkalemia. This open-label study compares the efficacy and safety of patiromer administeredwithout food versuswith food.Methods: Adults with hyperkalemia (potassium ≥5.0 mEq/L) were randomized (1:1) to receive patiromer once dailywithout food orwith food for 4 weeks. The dosage was adjusted (maximum: 25.2 g/day) using a prespecified titration schedule to achieve and maintain potassium within a target range (3.8-5.0 mEq/L). The primary efficacy endpoint was the proportion of patients with serum potassium in the target range at either week 3 or week 4. Safety was assessed by adverse events (AEs) and laboratory testing.Results: Efficacy was evaluated in 112 patients; 65.2% were ≥65 years of age, 75.9% had chronic kidney disease, and 82.1% had diabetes. Baseline mean serum potassium was similar in thewithout-food (5.44 mEq/L) andwith-food (5.34 mEq/L) groups. The primary endpoint was achieved by 87.3% (95% CI 75.5-94.7) and 82.5% (95% CI 70.1-91.3) of patients in thewith-food andwithout-foodgroups, respectively; least squares mean changes in serum potassium from baseline to week 4 were -0.65 and -0.62 mEq/L, respectively (p
Source: American Journal of Nephrology - Category: Neurology Source Type: research

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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: The addition of AST-120 to conventional treatments may delay the progression of renal dysfunction in diabetic nephropathy. The antioxidant effect of AST-120 might contribute to improvement in renal function. PMID: 31001934 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Anogenital skin care for elderly remains an umbrella term concerning protective and non-interventional regimens, particularly for ordinary diaper users. Diapers provide an anxiety relief for excretion, but instead raise a prevalence of genital candidiasis. Our recent investigation has demonstrated the favorable preventive effect of topical washing with miconazole nitrate-containing soap to diaper candidiasis. We extended this work to the therapeutic benefit of the antifungal soap in substantial cases with genital candidiasis, who had at least 1 additional risk factor including diarrhea, cerebrovascular diseases, dementia, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
FRIDAY, April 19, 2019 -- Atrasentan is associated with a reduced risk for renal events in patients with type 2 diabetes and chronic kidney disease, according to a study published online April 14 in The Lancet to coincide with the International...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Conditions:   Diabetes Mellitus, Type 2;   Renal Insufficiency, Chronic Interventions:   Drug: Metformin;   Drug: Sulfonylurea;   Drug: DPP-4 inhibitor;   Drug: SGLT2 inhibitor;   Drug: GLP1 receptor agonist Sponsors:   Weill Medical College of Cornell University;   Patient-Centered Outcomes Research Institute Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: May 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 5Author(s): Hiddo J L Heerspink, Josef Coresh, Ron T Gansevoort, Lesley A Inker
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: May 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 5Author(s): Hai-Lu Zhao, Yao Lu, Wei Ling
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Authors: Furuya F, Ishii T, Kitamura K Abstract BACKGROUND: From a global perspective, diabetic kidney disease (DKD) is the leading cause of not only chronic kidney disease and end-stage renal disease but also cardiovascular disease (CVD). SUMMARY: In the early stages of diabetes, patients have a high risk of developing microvascular complications, loss of kidney function, CVD, infection, and death. Hyperglycemia, free fatty acids, and insulin resistance induce metabolic imbalance and DKD initiation. Inflammation is recognized to play a role in DKD pathogenesis. Our recent study indicated that angiopoietin-like...
Source: Contributions to Nephrology - Category: Urology & Nephrology Tags: Contrib Nephrol Source Type: research
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