Reactions between methylglyoxal and its scavengers in-vivo appear to be catalyzed enzymatically

Methylglyoxal (MGO) is an important contributor to the development of diabetic complications. In this paper I propose that MGO, not detoxified by the glyoxalase system, is removed from circulation by MGO-scavengers. Furthermore, since rates of reactions between MGO and its scavengers in-vitro are low, I propose that in-vivo these reactions are catalyzed enzymatically.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research