Space Invaders: Brain Tumor Exploitation of the Stem Cell Niche
Increasing evidence indicates that the adult neurogenic niche of the ventricular sub-ventricular zone (V-SVZ), beyond serving as a potential site of origin, affects the outcome of malignant brain cancers. Glioma contact with this niche predicts worse prognosis, suggesting a supportive role for the V-SVZ environment in tumor initiation or progression. In this review, we describe unique components of the V-SVZ that may permit or promote tumor growth within the region. Cell-cell interactions, soluble factors, and extracellular matrix composition are discussed, and the role of the niche in future therapies is explored.
Source: American Journal of Pathology - Category: Pathology Authors: Justine Sinnaeve, Bret C. Mobley, Rebecca A. Ihrie Tags: Review Source Type: research
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