[18F]-Sodium Fluoride PET MR-Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint-Induced Disability [SPINE]

SUMMARY:
Our aim was to prospectively evaluate the relationship between low back pain–related disability and quantitative measures from [18F]-sodium fluoride ([18F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [18F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlation was observed between maximum facet joint uptake rate and clinical disability (P < .05). These data suggest that dynamic [18F]-NaF PET may serve as a useful biomarker for facetogenic disability.

Source: American Journal of Neuroradiology - October 6, 2017 Category: Radiology Authors: Jenkins, N. W., Talbott, J. F., Shah, V., Pandit, P., Seo, Y., Dillon, W. P., Majumdar, S. Tags: SPINE Source Type: research