The multidimensional nucleus

Nature Genetics 49, 1415 (2017). doi:10.1038/ng.3971 This issue highlights a range of genetic techniques and cell biological models required to begin to understand the levels of long-range regulation of gene expression as it occurs during cell differentiation. Explanations based on the specificity of covalent modifications and binding interactions intersect with evidence for conjectured mechanisms of topological loop creation and maintenance by transcription and motile protein activities.
Source: Nature Genetics - Category: Genetics & Stem Cells Tags: Editorial Source Type: research
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