Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity resulting in symptoms or complications. The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx. GERD affects quality of life and may cause erosive esophagitis, esophageal strictures, and Barrett esophagus, a precursor to esophageal adenocarcinoma. GERD is a clinical diagnosis and is most effectively treated with proton-pump inhibitors (PPIs). Long-term use of PPIs is associated with bone fractures, chronic renal disease, acute renal disease, community-acquired pneumonia, and Clostridium difficile intestinal infection.
Source: Primary Care: Clinics in Office Practice - Category: Primary Care Authors: Source Type: research

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Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): S. Cakmak, E. Koseoglu, K. Tarim, A.E. Canda, M.C. Kiremit, Y. Kordan, A. Armutlu, D. Ertoy, M.D. Balbay, T. Esen
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 September 2019Source: International Journal of Surgery Case ReportsAuthor(s): Shin Takayama, Kaishi Satomi, Masayuki Yoshida, Chikashi Watase, Takeshi Murata, Sho Shiino, Kenjiro Jimbo, Akihiko SutoABSTRACTINTRODUCTIONSpontaneous regression of a malignant tumor is defined as “the partial or complete disappearance of a malignant tumor in the absence of any treatment.” Herein, we report a case of occult breast cancer with axillary lymph node metastasis that showed spontaneous tumor regression based on the histopathological findings.PRESENTATION OF THE CASEA 67-year-old woman ...
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 21 September 2019Source: Cirugía Española (English Edition)Author(s): Alexis Luna Aufroy, Salvador Navarro SotoAbstractPreoperative clinical staging is critical to select those patients whose disease is localized and may benefit from surgery with curative intent. Ideally, such staging should predict tumor invasion, lymphatic involvement and distant metastases. With the cTNM, we are able to select patients who could benefit from endoscopic resection, radical surgery or less radical treatment in patients with distant metastasis. The initial diagnosis of adenocarcinomas of the ...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 21 September 2019Source: Cirugía Española (English Edition)Author(s): Javier Escrig Sos, Luis Gómez Quiles, Karina MaiocchiAbstractThe new 8th edition of the TNM classification system for esophageal and cardia or esophagogastric junction cancer provides important innovations in the TNM stages. Two classifications are presented, updated by stages, clinical (cTNM) and pathological (pTNM) methods, together with another pathological classification applicable to cases receiving neoadjuvant treatment (ypTNM). There is a notable increase in complexity compared to previous ve...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Authors: Kamyabi N, Bernard V, Maitra A Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a disease of near uniform lethality. Invasive tissue biopsies of primary or metastatic lesions remain the gold standard for diagnosis, but repeated sampling is infeasible. Non-invasive liquid biopsies, which better represent the heterogeneity of PDAC, offer new opportunities for early diagnosis during surveillance in high-risk cohorts, and for the longitudinal analysis of tumor evolution and progression in patients on therapy. In particular, liquid biopsies can capture tumor-associated components, such as circu...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Authors: Alterio T, Cardile S, Trayers C, Valenti S, Loddo I, Mardare R, Mosca A, Nobili V Abstract Eosinophilic Esophagitis (EoE) is a chronic immune/antigen-mediated condition which is also driven by genetic and environmental factors. It has been deeply investigated over the last years and its incidence is widely increasing in childhood. Although atopic diseases are closely linked with EoE, it does not recognize a classical IgE-mediate immune pathogenesis but it is rather a T helper type 2 inflammatory process. Familial clustering supports genetic predisposition in EoE and recent advances in understanding the gen...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
We present a case of a patient with drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine combined with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) caused by interstitial pneumonia (IP). A 67-year-old man with a past history of rheumatism (RA) presented with right hemiparalysis and aphasia as the chief complaints. A diagnosis of left embolic cerebral infarction following trial therapy for RA based on computed tomography findings was made, and external decompression was performed. Salazosulfapyridine was newly started on day 7. Dabigatran was started on day 37. On day 41, the pa...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Publication date: Available online 17 September 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Serhat BorAbstractThe pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor. S...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
This study enrolled 2,940 subjects, including patients with GC (n=1,124) or gastric dysplasia (n=353) and controls (n=1,463). Tests to determine sPG levels and Helicobacter pylori (HP) infection status were performed. Area under the curve and receiver operating characteristic curve were calculated to identify the optimal cutoff values for sPG. The usefulness of sPG levels for the detection of GC and gastric dysplasia was validated by multivariate logistic regression. Results: The sPGI/II ratio was associated with the risk of gastric dysplasia and advanced-stage intestinal-type GC (IGC). In contrast, sPGII was associate...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Conclusions: Chromosomal alterations were frequently identified in both PDAC and IPMN with similar patterns. CEP18 gain and 17p and 18q deletions might be involved in the later stages of PDAC tumorigenesis. Chromosome 17p and 18q deletions might be excellent diagnostic markers. PMID: 31533396 [PubMed - as supplied by publisher]
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
More News: Acid Reflux | Adenocarcinoma | Clostridium Difficile | Erosive Esophagitis | Esophagus Cancer | Gastric (Stomach) Cancer | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Heartburn | Orthopaedics | Pneumonia | Primary Care | Proton Pump Inhibitors PPIs