Atypical Depression and Non-Atypical Depression: Is HPA Axis Function a Biomarker? A Systematic Review

The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i.e.
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Review article Source Type: research