DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer.

CONCLUSIONS: Expression of DNA metabolic related genes RAD51, GINS1, TRIP13 and MCM2 are associated with poor outcome. Combinations of some of these genes are linked to poor RFS or OS in luminal A, B and ER+HER2- tumors. Evaluation of its predictive capacity in prospective studies is required. PMID: 28968952 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/28968952?dopt=Abstract

Source: Oncotarget - October 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research