The Contribution of Neanderthals to Phenotypic Variation in Modern Humans

Assessing the genetic contribution of Neanderthals to non-disease phenotypes in modern humans has been difficult because of the absence of large cohorts for which common phenotype information is available. Using baseline phenotypes collected for 112,000 individuals by the UK Biobank, we can now elaborate on previous findings that identified associations between signatures of positive selection on Neanderthal DNA and various modern human traits but not any specific phenotypic consequences. Here, we show that Neanderthal DNA affects skin tone and hair color, height, sleeping patterns, mood, and smoking status in present-day Europeans.

Source: The American Journal of Human Genetics - October 5, 2017 Category: Genetics & Stem Cells Authors: Michael Dannemann, Janet Kelso Tags: Article Source Type: research